概述| 货号 | RDC0257 |
| 别名 | ADRA2B adrenergic, alpha-2B-, receptor; ADRA2B; ADRA2L1; ADRA2L1adrenergic receptor alpha 2B; ADRA2RL1; ADRARL1; adrenergic, alpha-2B-, receptor; Alpha-2 adrenergic receptor subtype C2; alpha-2-adrenergic receptor-like 1; alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; Alpha-2B adrenoreceptor; alpha-2B-adrenergic receptor; ALPHA2BAR; alpha-2BAR; G-protein coupled receptor |
全称 | Alpha-2B Adrenergic Receptor | | 反应种属 | Human |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 151 (Human); 11552 (Mouse); 24174 (Rat) |
| 背景 | Alpha-2-adrenergic receptors, including ADRA2B, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C that have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. ADRA2B was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of ADRA2B was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Neurotransmitter G Protein-Coupled Receptors
- Obesity
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