Cynomolgus Monkey VISTA/B7-H5/PD-1H (XP 005565644) cDNA ( )
货号：
RDC1689 基本售价：
2825.6 元 规格：
10 ug
产品信息
概述| 货号 | RDC1689 |
| 别名 | 4632428N05Rik; B7H5; B7-H5; C10orf54; chromosome 10 open reading frame 54; Dies1; Gi24; PD-1H; platelet receptor Gi24; PP2135; SISP1; stress induced secreted protein 1 |
| 反应种属 | Cynomolgus Monkey |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 64115 (Human); 74048 (Mouse); 690899 (Rat) |
| 背景 | VISTA, also known as B7-H5, PD-1H, platelet receptor Gi24, Dies1, and SISP1, is a transmembrane glycoprotein that promotes both MT1-MMP expression and the MT1-MMP mediated activation of MMP-2. VISTA supports the differentiation of embryonic stem cells (ESC) and enhances BMP-4 induced signaling in ESC but is also downregulated following BMP-4 exposure. It binds to BMP-4 directly and also associates with the type I BMP receptor Activin RIB/ALK-4. VISTA is expressed on the surface of naïve CD4+ T cells, regulatory T cells, and adipocytes. It is upregulated in vivo on activated monocytes and dendritic cells. VISTA inhibits CD4+ and CD8+ T cell proliferation and their production of IL-2 and IFN-gamma. Its expression on tumor cells attenuates the anti-tumor immune response and enables more rapid tumor progression. In contrast, VISTA limits disease progression in the autoimmune disease model EAE. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 参考文献 | - Coagulation
- Co-stimulatory and Co-inhibitory Molecules
- Embryonic and Induced Pluripotent Stem Cell Markers
- ICC / IHC Images: VISTA/B7-H5/PD-1H
- Metalloproteases and Regulators
- MMPs, TIMPs and Related Molecules
- Platelets
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