| 货号 | 39879 |
| 克隆类别 | 29D1 |
| 别名 | WHS, NSD2, TRX5, REIIBP |
| 同种亚型 | IgG2b |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | ChIP/ChIP-Seq/Western Blot/Immunofluorescence/Immunocytochemistry |
| 使用方法 | Validated Applications: ChIP: 2 - 5 µg per ChIP ChIP-Seq: 10 µg each ICC/IF: 0.5 µg/ml dilution Published Applications: WB See references for more information. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This MMSET / WHSC1 antibody was raised against a recombinant protein corresponding to amino acids 1-647 of human MMSET-I. |
| 背景 | MMSET(Multiple Myeloma SET domain-containing protein) / WHSC1(Wolf-Hirschhorn Syndrome Candidate 1; also known as NSD2,Nuclear Receptor binding SET domain protein 2;TRX5,Trithorax 5) is a SET domain-containing histone methyltransferase specific for lysine 36 of histone H3. The MMSET / WHSC1 gene is deleted in Wolf-Hirschhorn syndrome, a disorder characterized by developmental defects and mental retardation. In 15% of patients with Multiple Myeloma (MM), a chromosomal translocation leads to MMSET / WHSC1 gene being aberrantly placed under the control of the IgH intronic µ enhancer and expressed at very high levels. This event is apparently a key component in cellular transformation leading to MM. Reduction in MMSET / WHSC1 expression in a myeloma cell line suppressed its growth, suggesting a role for MMSET in maintaining the transformed state. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 88 & 157 kDa |
| 参考文献 |
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MMSET / WHSC1 antibody (mAb) tested by Immunofluorescence. Formaldehyde fixed HeLa cells stained with MMSET / WHSC1 antibody at a 0.5 µg/ml dilution. |
