| 货号 | 61477 |
| 克隆类别 | 6A4 |
| 别名 | DNA Methyltransferase 3a, DNMT3A2 |
| 同种亚型 | IgG2a |
| 反应种属 | Human, Mouse, Other (Wide Range) |
| 来源宿主 | Rat |
| 应用 | Immunofluorescence/Immunocytochemistry |
| 使用方法 | Published Applications: ICC/IF See references for more information. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This antibody was raised against a synthetic peptide corresponding to amino acid residues 200 - 215 of human DNMT3A. |
| 背景 | DNMT3A (DNA (cytosine-5)-methyltransferase 3A) is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity). |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 130 kDa |
| 参考文献 |
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