| 货号 | 39885 |
| 克隆类别 | 328.8b |
| 别名 | AICDA, ARP2, CDA2, HIGM2, HEL-S-284 |
| 同种亚型 | IgG2a |
| 反应种属 | Human, Mouse |
| 来源宿主 | Rat |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1 - 3 µg/ml dilution |
| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This AID antbody was raised against a peptide corresponding to amino acids 178-198 of human AID. |
| 背景 | AID(Activation-induced cytidine deaminase,AICDA) is a member of the cytidine and deoxycytidylate deaminase family. It acts act as a single-strand DNA deaminase involved in somatic hypermutation, gene conversion and class-switch recombination in developing B-cells and is necessary for efficient antibody responses. It has also been implicated in active DNA demethylation, as deamination of methylcytosine yields thymine, which is read as a mismatch and is replaced by DNA damage repair enzymes. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 50 mM Tris-HCl (pH 7.2), 30% glycerol, and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 24 kDa |
| 参考文献 |
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AID antibody (mAb) tested by Western blot. Murine spleen cells were probed with AID antibody at a dilution of 3 µg/ml. Lane 1: Unstimulated spleen cells from wild type mice. Lane 2: Treated (LPS & IL4 for 96 hrs) spleen cells from wild type mice. Lane 3: Unstimulated spleen cells from AID knock-out mice. Lane 4: Treated (LPS & IL4 for 96 hrs) spleen cells from AID knock-out mice. |
