| 货号 | 61135 |
| 别名 | GMNN, GEM |
| 同种亚型 | Serum |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot/Immunoprecipitation |
| 使用方法 | Published Applications: IP WB See references for more information. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | None |
| 免疫原 | This Geminin antibody was raised against full-length recombinant human Geminin protein. |
| 背景 | Geminin is a crucial cell cycle regulatory protein that controls DNA replication and centrosome function. Geminin inhibits DNA replication by preventing the binding of the MCM complex into the pre-replication complex. Geminin accumulates during S, G2, and M phases, and disappears at the time of the metaphase-anaphase transition. Geminin functions as a homotetramer and interacts with DNA replication licensing factor CDT1. The interaction between Geminin and CDT1 is crucial to restrict DNA replication to once per cell cycle. Geminin is required for the formation of pluripotent cells in the developing embryo and essential for pluripotency in the embryonic stem cells. In ESCs, Geminin remains during G1 and sustains core pluripotency factors (Oct4, Sox2, and Nanog) by antagonizing the action of the chromatin remodeling protein BRG1. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 33 kDa |
| 参考文献 |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |