| 货号 | 61051 |
| 别名 | EVI9, ZNF856, HBFQTL5, BCL11A-L, BCL11A-S, BCL11a-M, BCL11A-XL |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot/Immunoprecipitation |
| 使用方法 | Validated Applications: IP: 5 - 10 µl per IP WB: 1:1,000 - 1:5,000 dilution |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This BCL11A / CTIP1 antibody was raised against a peptide within the N-terminal region of human BCL11A / CTIP1. |
| 背景 | BCL11A/CTIP1(B-cell CLL/lymphoma 11A,COUP-TF-interacting protein 1) is a transcriptional regulator, a myeloid and B-cell proto-oncogene and plays important roles in leukemogenesis and hematopoiesis. BCL11A/CTIP1 is involved in regulating hemoglobin gene expression. BCL11A regulates hemoglobin gene switching during fetal development and silencing of γ-globin expression in adults. BCL11A interacts with the Mi-2/NuRD chromatin remodeling complexes, as well as the erythroid transcription factors GATA1 and FOG1. Abundant expression of full-length forms of BCL11A is developmentally restricted to adult erythroid cells. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 130 kDa |
| 参考文献 |
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BCL11A / CTIP1 antibody (pAb) tested by Immunoprecipitation. 10 µl of BCL11A / CTIP1 antibody was used to immunoprecipitate BCL11A / CTIP1 from 250 µg of Raji nuclear cell extract (lane 2). 10 µl of rabbit IgG was used as a negative control (lane 1). The immunoprecipitated protein was detected by Western blotting using the BCL11A / CTIP1 antibody at a dilution of 1:1,000. | |
BCL11A / CTIP1 antibody (pAb) tested by Western blot. Nuclear extract of Raji cells (20 µg per lane) probed with BCL11A / CTIP1 antibody at a dilution of 1:1,000. |
