| 货号 | 61047 |
| 别名 | ERR1, ERRa, ESRL1, NR3B1, ERRalpha |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1:500 - 1:1,000 dilution |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This ERR-alpha antibody was raised against a peptide within the C-terminal region of human ERR alpha. |
| 背景 | ERR-α(Estrogen-related receptor alpha, NR3B1) is an orphan nuclear receptor similar to the Estrogen Receptor. It is a sequence-specific DNA binding transcriptional activator that is constitutively active in the absence of ligand binding. No true physiological ligands have been found, but estrogen-like compounds from plants have been shown to activate ERR-α. ERR-α and ER-α have been found to regulate an overlapping set of genes, and ERR-α appears to modulate the activity of ER-α in some tissue types. ERR-α regulates genes involved in mitochondrial biogenesis, gluconeogenesis, oxidative phosphorylation, and fatty acid metabolism. ERR-α knockout mice display impaired fat metabolism and absorption. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 50 kDa |
| 参考文献 |
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Western blot of ERR-α antibody. Nuclear extract of MDA-MB-231 cells (20 µg per lane) probed with ERR alpha antibody at a dilution of 1:500. |
