| 货号 | 40923 |
| 别名 | STK17A |
| 同种亚型 | IgG |
| 反应种属 | Human, Mouse |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1 - 2 µg/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This DRAK1 antibody was raised against a peptide corresponding to amino acid residues 5 to 9 of human DRAK1. |
| 背景 | Overexpression of DRAK1(STK17AorDAP kinase-related apoptosis-inducing protein kinase 1) and ZIP kinase can cause the morphological changes typical of apoptosis in NIH/3T3 cells. Both DRAKs and ZIP kinase share significant homology at the amino acid level. The kinase domains of both DRAKs and ZIP kinase are homologous to DAP(Death-associated protein)kinase, which is involved in the apoptotic signaling induced by interferon-γ. Overexpression of DRAKs in NIH/3T3 cells lead to apoptosis. These experiments also indicate that the C-terminal domain of DRAKs are important for induction of apoptosis. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 56 kDa |
| 参考文献 |
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DRAK1 pAb tested by Western blot. Detection of DRAK1 by Western blot. The analysis was performed using MOLT4 (lane 1), A-431 (lane 2) and NIH/3T3 (lane 3) nuclear extracts and DRAK1 pAb at a 2 µg/ml dilution. |
