| 货号 | 39985 |
| 别名 | Apolipoprotein B mRNA-editing enzyme catalytic subunit 2, ARP1, ARCD1 |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1:500 - 1:2,000 dilution |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This APOBEC2 antibody was raised against a peptide derived from the N-terminal region of human APOBEC2. |
| 背景 | APOBEC2(Apolipoprotein B mRNA-editing enzyme catalytic subunit 2) is part of a family of enzymes that edit nucleic acids, possibly changing cytosine to uracil. APOBEC2 expression is regulated by TNF-α via NFκB activation and this suggests a possible role for APOBEC2 in the pathophysiology of hepatic inflammation. APOBEC2 has a low intrinsic cytidine deaminase activity and is also involved in DNA demethylation. APOBEC2 deaminates 5-methylcytosine, followed by base excision repair by Mbd4. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 35 kDa |
| 参考文献 |
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APOBEC2 antibody (pAb) tested by Western blot. Nuclear extract (20 µg) of L6E9 cells (Lane 1) or nuclear extract (20 µg) of C2C12 cells (Lane 2) probed with APOBEC2 antibody at a 1:2,000 dilution. |
