| 货号 | 39859 |
| 别名 | PPARGC1B, PERC, ERRL1, PGC1B |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1:500 - 1:2,000 dilution The addition of 0.05% Tween 20 in the blocking buffer and primary antibody incubation buffer is recommended to aid in detection by Western blot. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This PGC1-β antibody antibody was raised against a peptide within the N-terminal region of human PGC1-β. |
| 背景 | PGC1-β(Peroxisome proliferator-activated receptor gamma coactivator 1-beta,PPARGC1B,PERC) is a co-activator of transcription by nuclear receptors and transcription factors. PGC1-β participates in modulating the transcriptional activity of PPAR alpha and gamma, ER alpha, NRF1 and GR. It is likely involved in fat oxidation, non-oxidative glucose metabolism and in the regulation of energy expenditure. Expression of PGC1-β is repressed by saturated fatty acids in skeletal muscle cells and induced by insulin. PGC1-β is down-regulated in type 2 diabetes as well as in pre-diabetics. Allelic variation of PGC1-β may contribute to the pathogenesis of obesity, with the widespread Ala-203 variation being a significant risk factor for the development of this diabetes. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 150 |
| 参考文献 |
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PGC1-β antibody tested by Western blot. Western blot of K-562 nuclear extract (40 µg/lane) probed with PGC1-β antibody (pAb) (1:500 dilution). |
