| 货号 | 39761 |
| 别名 | B-Cell CLL/Lymphoma 3, B-Cell Lymphoma 3-Encoded Protein, BCL4, D19S37 |
| 同种亚型 | Serum |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1:500 - 1:2,000 dilution |
| 供应商 | Active Motif |
| 纯化方式 | None |
| 免疫原 | This Bcl3 antibody was raised against a peptide within the C-terminal half of human Bcl3. |
| 背景 | Bcl3(B-cell lymphoma 3 protein) functions as a transcriptional co-activator that activates through its association with NFkBhomodimers.Bcl3 contains seven ankyrin repeats, which are most closely related to those found in IkB proteins. Bcl3 also functions as a form of IkB specific for the NFkB p50 subunit inhibiting its translocation to the nucleus. The expression of this gene can be induced by NFkB, which forms a part of the autoregulatory loop that controls the nuclear residence of NFkB p50.Bcl3 is overexpressed in a number of cancers, can transform fibroblasts and induce tumors in nude mice, thus implicating Bcl3 as a proto-oncogene. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 60 kDa |
| 参考文献 |
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Bcl3 antibody tested by Western blot. Detection of Bcl3 by Western blot analysis. Lane 1: HeLa whole-cell extract (20 µg). Lane 2: Nuclear extract (20 µg) of Raji cells. Both probed with Bcl3 antibody at a dilution of 1:1,000. |
