| 货号 | 39711 |
| 别名 | JHDM1F, MRXSSD, ZNF422 |
| 同种亚型 | Serum |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1:500 - 1:2,000 dilution |
| 供应商 | Active Motif |
| 纯化方式 | None |
| 免疫原 | This PHF8 antibody was raised against a synthetic peptide derived from human PHF8. |
| 背景 | PHF8(PHD finger protein 8) is a member of the JmjC-containing (Jumonji-C) class of histone demethylase proteins that are involved in the regulation of genome function through the removal of methyl groups from histones. PHF8 also has an N-terminal PHD finger and demethylates Histone H3 monomethyl Lys9 (H3K9me1) and Histone H3 dimethyl Lys9 (H3K9me2), Histone H3 dimethyl Lys27 (H3K27me2) (which are all modifications associated with transcriptional repression) and also Histone H3 dimethyl Lys36 (H3K36me2). Defects in PHF8 lead to Siderius type X-linked mental retardation (MRXSSD). |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 135 kDa |
| 参考文献 |
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PHF8 pAb tested by Western blot. Nuclear extract of HeLa cells (20 µg) was probed with PHF8 pAb (1:500 dilution). |
