| 货号 | 39226 |
| 别名 | MMS2, UEV2, EDPF1, UEV-2, DDVIT1, EDAF-1, EDPF-1, DDVit-1 |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1 - 3 µg/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This UBE2V2 antibody was raised against a peptide corresponding to amino acid residues 12-28 of human UBE2V2. |
| 背景 | UBE2V2–Ubiquitin-Conjugating Enzyme E2 Variant 2 is a member of the Ubiquitin-conjugating E2 family of proteins but lacks the conserved cysteine residue that is critical for the catalytic activity of E2 enzymes and has no intrinsic E2 ligase activity. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and the yeast MMS2 gene product. It forms a heterodimer with UBE2N and catalyzes the synthesis of poly-ubiquitin chains that are linked through Lys63, which does not lead to protein degradation by the proteasome. Instead, it mediates transcriptional activation of target genes, plays a role in the control of progress through the cell cycle as well as differentiation. It also plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 15 kDa |
| 参考文献 |
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UBE2V2 pAb tested by Western blot. Detection of UBE2V2 by Western blot. The analysis was performed using HL-60 whole-cell extract and UBE2V2 pAb at a 2 µg/ml dilution. |
