| 货号 | 39225 |
| 别名 | CIR1, UEV1, CROC1, UBE2V, UEV-1, UEV1A, CROC-1 |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1 - 3 µg/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This UBE2V1a antibody was raised against a peptide corresponding to amino acid residues 31-49 of human UBE2V1a. |
| 背景 | UBE2N and its variants UBE2V1α and β are members of the E2 ubiquitin-conjugating enzyme family, and the homologs of yeast UBC13. The UBE2V1/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK (IKKα, IKKβ Clone 10AG2, IKKβ Clone 10A9B6, IKKγ) and does not seem to involve protein degradation by the proteasome. UBE2V1 plays a role in the activation of NFκB (NFκB p50, NFκB p65) mediated by IL-1β, TNF, TRAF6 and TRAF2. |
| 运输条件 | Blue Ice |
| 存放说明 | Some products may be shipped at room temperature. This will not affect their stability or performance. Upon receipt, unconjugated antibodies may be stored at -20°C for up to 2 years. Fluorophore- & enzyme-conjugated antibodies should be stored at 4°C. Fluorophore-conjugated antibodies should be protected from light. Keep reagents on ice when not in storage; to avoid repeated freeze/thaw cycles, we recommend aliquoting items that will be stored frozen into single-use fractions prior to freezing. |
| 存储溶液 | PBS containing 0.2% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 20 kDa |
| 参考文献 |
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