| 货号 | 39059 |
| 别名 | CANDF7, ISGF-3, STAT91 |
| 同种亚型 | Serum |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1:500 - 1:1,000 dilution For optimal results, primary antibody incubations should be performed at 37°C. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | None |
| 免疫原 | This STAT1α antibody was raised against a synthetic peptide corresponding to amino acid residues 712-750 of human STAT1α. |
| 背景 | STAT1 is alternatively spliced to give rise to STAT1α and STAT1β, both of which mediate interferon α activity, but only STAT1α mediates interferon-γ activity. STAT1 plays a critical role in various forms of cell death, both apoptotic and non-apoptotic. The mechanisms of action are both by transcriptional activation of target genes, and by direct association with apoptotic regulators, including TRADD, p53, and HDAC (HDAC1, HDAC2, HDAC4, HDAC5, HDAC6 and HDAC11). STAT1 target genes include the pro-inflammatory genes for iNOS, COX, VCAM, and ICAM, making STAT1 an attractive anti-inflammatory target. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | PBS containing 0.2% gelatin, 0.01% thimersol and 0.1% sodium azide. Thimersol and sodium azide are highly toxic. |
| 计算分子量 | 91 kDa |
| 参考文献 |
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STAT1α pAb tested by Western blot. Detection of STAT1α by Western blot analysis. STAT1α was detected in whole-cell extracts derived from T-47D cells using STAT1α rabbit polyclonal antibody at a 1:500 dilution. Several uncharacterized bands of approximately 78 and 140 kDa may also be revealed under the same conditions. |
