| 货号 | 39373 |
| 别名 | NBN, ATV, NBS, P95, AT-V1, AT-V2 |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1:500 - 1:1,000 dilution |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This NBS1 antibody was raised against a peptide containing to the C-terminus of human NBS1. |
| 背景 | NBS1(Nijmegen breakage syndrome 1,NBNorp95) is a component of the MRE11/RAD50/NBN (MRN complex), which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3′-5′ exonuclease activity, which are provided by MRE11A. NBN modulate the DNA damage signal sensing by recruiting PI3-kinase/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. NBS1(NBN) also functions in telomere length maintenance by generating the 3′ overhang which serves as a primer for telomerase dependent telomere elongation. NBS1(NBN) is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBS1(NBN) is involved in G1 and G2 checkpoints. The roles of NBS1(NBN)/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 95 kDa |
| 参考文献 |
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NBS1 pAb tested by Western blot. Nuclear extract of HeLa cells (20 µg) was probed with NBS1 pAb (1:500 dilution). |
