| 货号 | 39261 |
| 别名 | Aurora Kinase B, AurB, ARK2 |
| 同种亚型 | Serum |
| 反应种属 | Human, Mouse, Other (Wide Range) |
| 来源宿主 | Rabbit |
| 应用 | Western Blot/Immunofluorescence/Immunocytochemistry |
| 使用方法 | Validated Applications: ICC/IF: 1:200 - 1:1,000 dilution WB: 1:500 - 1:5,000 dilution |
| 供应商 | Active Motif |
| 纯化方式 | None |
| 免疫原 | This Aurora B antibody was raised against a peptide including the C-terminus of human Aurora B. |
| 背景 | Aurora B(Aurora Kinase B,AurB,ARK2) is a Ser/Thr kinase that is part of the chromosomal passenger complex that associates with chromosomes and is an important regulator of mitosis and meiosis. Aurora B becomes concentrated at the centromere during the onset of mitosis, but relocates to the spindle midzone during anaphase. Aurora B phosphorylates a number of substrates, including INCENP, CENP-A, and Histone H3. Misregulation of Aurora B activity can lead to chromosome instability and is implicated in a number of cancers. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 49 kDa |
| 参考文献 |
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Aurora B pAb tested by immunofluorescence. Top left: HeLa cells stained with Aurora B polyclonal antibody at a 1:200 dilution. Top right: Same cells stained with alpha Tubulin mAb. Bottom left: Same cells stained with DAPI. Bottom right: Merge of all 3 images. | |
Aurora B pAb tested by Western blot Nuclear extract of U2OS cells (20 µg per lane) probed with Aurora B polyclonal antibody (1:500 dilution). |
