| 货号 | 39247 |
| 别名 | KDM4D |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1:500 - 1:2,000 dilution |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This JMJD2D antibody was raised against a peptide corresponding to amino acids 337-359 of human JMJD2D. |
| 背景 | JMJD2D(KDM4D) is a histone demethylase located in the nucleus that specifically demethylates Lysine 9 of Histone H3, thereby playing a central role in the histone code. JMJD2D(KDM4D) demethylates both di- or trimethylated histone H3 Lys 9, while it has no activity on monomethylated residues. The demethylation reaction of the Lys residue generates formaldehyde and succinate as a by product. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D(KDM4D) may be involved in carcinogenesis. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified rabbit IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 58 kDa |
| 参考文献 |
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JMJD2D pAb tested by Western blot. Nuclear extract of HeLa cells (20 µg) probed with JMJD2D pAb (1:1,000). Specificity was verified by peptide competition. Lane 1: No peptide. Lane 2: 1 µM immunizing peptide. |
