| 货号 | 39229 |
| 别名 | Lysine (K)-specific demethylase 5C, Jumonji, AT rich interactive domain 1C, |
| 同种亚型 | Serum |
| 反应种属 | Human, Mouse |
| 来源宿主 | Rabbit |
| 应用 | ChIP/Western Blot |
| 使用方法 | Validated Applications: ChIP: 10 µl per ChIP WB: 1:500 - 1:2,000 dilution Published Applications: WB |
| 供应商 | Active Motif |
| 纯化方式 | None |
| 免疫原 | This JARID1C / KDM5C antibody was raised against a peptide corresponding the C-terminus of human JARID1C. |
| 背景 | Lysine (K)-specific demethylase 5C (KDM5C), also known as Jumonji, AT rich interactive domain 1C (JARID1C), is a member of a family of histone demethylase enzymes that contain a Jumonji-N (Jmj-N) and Jumonji-C (Jmj-C) domain in addition to an AT-rich interacting domain (ARID). JARID1C also contains 2 PHD domains and a PLU-1 domain, and a putative DNA binding module. JARID1C demethylates histone H3 that has been di- or trimethylated at lysine 4, and functions as a repressor of transcription. JARID1C also participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in the JARID1C gene have been associated with X-linked mental retardation. |
| 运输条件 | Blue Ice |
| 存放说明 | Some products may be shipped at room temperature. This will not affect their stability or performance. Upon receipt, unconjugated antibodies may be stored at -20°C for up to 2 years. Fluorophore- & enzyme-conjugated antibodies should be stored at 4°C. Fluorophore-conjugated antibodies should be protected from light. Keep reagents on ice when not in storage; to avoid repeated freeze/thaw cycles, we recommend aliquoting items that will be stored frozen into single-use fractions prior to freezing. |
| 存储溶液 | Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 180 kDa |
| 参考文献 |
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