| 货号 | 61335 |
| 克隆类别 | 2TRR-1B3 |
| 别名 | Tra1, TR-AP, PAF400, STAF40, PAF350/400 |
| 同种亚型 | IgG2a |
| 反应种属 | Human, Mouse |
| 来源宿主 | Mouse |
| 应用 | ChIP/Immunoprecipitation |
| 使用方法 | Published Applications: ChIP IP See references for more information. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This antibody was raised against a synthetic peptide corresponding to amino acid residue(s) 2023-2042 of human Trrap. |
| 背景 | Trrap (transformation/transcription domain-associated protein) is an adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 32 mM glycine, 0.07 mM EDTA, 30% glycerol, and 0.035% sodium azide. |
| 计算分子量 | 450 kDa |
| 参考文献 |
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