| 货号 | 61073 |
| 克隆类别 | 7A11 |
| 别名 | SUH, csl, AOS3, CBF1, KBF2, RBP-J, RBPJK, IGKJRB, RBPSUH, IGKJRB1 |
| 同种亚型 | IgG2b |
| 反应种属 | Human |
| 来源宿主 | Rat |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 2 - 4 µg/ml dilution Published Applications: see references |
| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This antibody was raised against full-length recombinant human RBPJ protein. |
| 背景 | RBPJ (Recombination Signal Binding Protein For Immunoglobulin Kappa J Region) is a transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 55 kDa |
| 参考文献 |
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Western blot of RBPJ antibody. Wild type (lane 1) or RBPJ KO (lane 2) DG75 cell lysate was probed with RBPJ antibody (top row) or a GAPDH antibody (bottom row) to show equal loading. |
