| 货号 | 40973 |
| 克隆类别 | 38C674 |
| 别名 | TP73 |
| 同种亚型 | IgG1 |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1 - 2 µg/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This p73DN antibody was raised against a peptide corresponding to amino acid residues 2-13 of human p73ΔN. This antibody does not cross react with full-length p73. |
| 背景 | p73ΔN is a member of the p53 protein family which includes p53 as well as p63. Whereas p53 transactivates the retinoblastoma gene, p63 and p73 induce the cyclin-dependent kinase inhibitor p57 to maintain Rb in an active, hypophosphorylated state. p73ΔN inhibits the functions of the p53 family in differentiation control, prevents myogenic differentiation, and enables cooperating oncogenes to transform myoblasts to tumorigenicity. p73ΔN is frequently overexpressed in rhabdomyosarcoma and is essential for tumor progression in vivo. These findings establish differentiation control as a key tumor suppressor activity of the p53 family. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 73 kDa |
| 参考文献 |
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