| 货号 | 40955 |
| 克隆类别 | 44C143 |
| 别名 | CD288 |
| 同种亚型 | IgG1 |
| 反应种属 | Human, Mouse |
| 来源宿主 | Mouse |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1 - 2 µg/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This TLR8 antibody was raised against a peptide corresponding to amino acid residues 750-850 of human TLR8. |
| 背景 | TLR8–Toll-Like receptor 8 is a member of the Toll-like receptor (TLR) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize specific molecular features associated with pathogens, and mediate the production of cytokines necessary for the development of effective immunity. Many of the TLRs heterodimerize with each other to modulate receptor function. TLR8 expression cells is elevated after exposure to both Gram-positive and Gram-negative bacteria. While primarily extracellular, TLR8 may be also localized intracellularly. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 120 kDa |
| 参考文献 |
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TLR8 mAb tested by Western blot. TLR8 detection by Western blot. The analysis was performed using TLR8 mAb and nuclear extract from 293 cells that had been transfected with human TLR8 cDNA. |
