| 货号 | 40938 |
| 克隆类别 | 98A1071 |
| 别名 | TNFRSF11B, TR1, OCIF |
| 同种亚型 | IgG1 |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1 - 2 µg/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This Osteoprotegerin (OPG) antibody was raised against a peptide corresponding to amino acid residues 20-37 of human Osteoprotegerin (OPG). |
| 背景 | Osteoprotegerin(OPG)/osteoclastogenesis inhibitory factor(OCIF) is a cytokine that can inhibit the production of osteoclasts. It is a member of the tumor necrosis factor (TNF) receptor superfamily. It is a basic glycoprotein comprising 401 amino acid residues arranged into 7 structural domains. It is found as either a 60 kDa monomer or 120 kDa dimer linked by disulfide bonds. Osteoprotegerin inhibits the differentiation of osteoclast precursors into osteoclasts and also regulates the resorption of osteoclasts in vitroandin vivo.Osteoprotegerin is a RANK homolog, and works by binding to RANKL ligand on osteoblast/stromal cells, thus blocking the RANKL-RANK ligand interaction between osteoblast/stromal cells and osteoclast precursors. This has the effect of inhibiting the differentiation of the osteoclast precursor into a mature osteoclast. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | PBS containing 0.02% gelatin and 0.05% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 55 kDa |
| 参考文献 |
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Osteoprotegerin (OPG) mAb tested by Western blot. Osteoprotegerin (OPG) mAb detection by Western blot. The analysis was performed using Daudi nuclear extract and Osteoprotegerin (OPG) mAb at a 2 µg/ml dilution. The immunoreactivity was detected by enhanced chemiluminescence. |
