| 货号 | 40909 |
| 克隆类别 | 108A429 |
| 别名 | NAK, T2K |
| 同种亚型 | IgG1 |
| 反应种属 | Human, Mouse, Rat |
| 来源宿主 | Mouse |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1 - 2 µg/ml dilution For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This TBK1 antibody was raised against a peptide corresponding to amino acid residues 563-577 of human TBK1. |
| 背景 | TBK1–TANK-binding kinase 1 is a regulator of the NFκB (NFκB p50 and NFκB p65) signaling pathway. NFκB signaling is controlled to a large extent by the sequestration of the NFκB complex in the cytoplasm by its association with one of the IκB family of proteins. IκB is phosphorylated by the IkB Kinase (IKK) complex, resulting in the degradation of IκB and the nuclear translocation of NFκB. TANK is an IκB family member that is specifically recognized and phosphorylated by TBK1, leading to the destruction of TANK and the activation of the NFκB pathway. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | PBS containing 0.02% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 80 kDa |
| 参考文献 |
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