HDAC1 antibody (mAb)
货号：
39881 基本售价：
6162.5 元 规格：
100 ug
产品信息
概述| 货号 | 39881 |
| 克隆类别 | 10E2 |
| 别名 | HD1, RPD3, GON-10, RPD3L1 |
| 同种亚型 | IgG1 |
| 反应种属 | Human, Mouse, Rat |
| 来源宿主 | Mouse |
| 应用 | Western Blot |
| 使用方法 |
Validated Applications:
WB: 0.5 - 2 µg/ml dilution |
性能| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This HDAC1 antibody was raised against a peptide corresponding to amino acids 467-482 of murine HDAC1. |
| 背景 | HDAC1(Histone Deacetylase 1, also designated HD1) is a member of the class I mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-ε-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the ε-amino group of a lysine residue.
In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs)andhistone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11).
HDAC1 and HDAC2 are recruited to Mad-Max complexes, which associate with the mSin3 scaffold protein, and are required for the transcriptional repression of Mad-Max target genes. HDAC1 is also involved in the regulation of p53. HDAC1 is expressed in various tissues. HDAC1, HDAC2 and HDAC3 are also ubiquitously expressed and can deacetylate both H3 and H4 in free histones or nucleosome substrate. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. For your convenience, a |
| 计算分子量 | 60 kDa |
| 参考文献 | |
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参考图片HDAC1 antibody (mAb) tested by Western blot.
Nuclear extract of HeLa cells (20 µg per lane) probed with HDAC1 antibody at a dilution of 1 µg/ml. |
