| 货号 | 39785 |
| 克隆类别 | MG44 |
| 别名 | MG44, KMT1A, SUV39H, H3-K9-HMTase 1 |
| 同种亚型 | IgG1 |
| 反应种属 | Human, Mouse |
| 来源宿主 | Mouse |
| 应用 | ChIP/Western Blot/Immunoprecipitation |
| 使用方法 | Published Applications: ChIP IP WB See references for more information. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This SUV39H1 antibody was raised against a recombinant protein corresponding to amino acids 1-126 of mouse SUV39H1. |
| 背景 | SUV39H1 is one of two homologues of the Drosophila Suppressor-of-variegation 3(9) protein (aka Su(var)3-9). SUV39H1 is a SET domain-containing histone methyltransferase specific for lysine 9 of histone H3. Lysine 9 methylation of histone H3 is found at regions of the genome that are transcriptionally silenced, such as centromeres, repetitive elements and inactive genes. H3 lysine 9 methylation is a hallmark of heterochromatin, regions of the genome that are in a tightly compacted state and relatively devoid of gene expression. HP1 proteins recognize and bind lysine 9 methylation and this contributes to maintaining heterochromatin in its compact and inactive state. SUV39H1 also contains a chromodomain, which may bind to lysine 9 methylation and contribute to the regional spreading of lysine 9 methylation and the establishment of heterochromatin over broader domains of the genome. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 50 kDa |
| 参考文献 |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |