| 货号 | 61140 |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Rabbit |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 1:500 - 1:1,000 dilution |
| 供应商 | Active Motif |
| 纯化方式 | Affinity Purified |
| 免疫原 | This AIRE antibody was raised against a peptide in the C-terminal region of human AIRE. |
| 背景 | AIRE (Autoimmune regulator, APECED, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) is a DNA-binding transcriptional regulator that promotes the expression of tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. AIRE functions as a dimer or as a tetramer and interacts with nucleosomes, selectively interacting with histone H3 unmodified in the N-terminus through its first of two PHD domains. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED) also known as autoimmune polyglandular syndrome type I (APS-1). |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in PBS with 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 60 kDa |
| 参考文献 |
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AIRE (pAb) tested by Western blot. Detection of AIRE by Western blot. The analysis was performed using 30 µg Hep G2 whole-cell extract and AIRE (pAb) at a 1:500 dilution. |
