| 货号 | 39824 |
| 同种亚型 | Serum |
| 反应种属 | Mouse |
| 来源宿主 | Rabbit |
| 应用 | Western Blot/Immunofluorescence/Immunohistochemistry/Immunocytochemistry |
| 使用方法 | Validated Applications: WB: 1:2,000 - 1:10,000 dilution Published Applications: IHC ICC/IF See references for more information. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | None |
| 免疫原 | This Sox2 antibody was raised against a peptide corresponding to amino acids amino acids 111-140 mouse Sox2. |
| 背景 | Sox2(SRY related HMG BOX gene 2) is a DNA binding transcription factor and a member of the SOX family of proteins. SOX proteins have an HMG box that binds DNA. Sox2 forms a complex with Oct-4 and controls the expression of a number of genes involved in embryonic. Sox2 is critical for early embryogenesis and for embryonic stem cell pluripotency and thus can serve as a stem cell marker. Overexpression of Sox2 (along with Oct-4, KLF4 and c-Myc) can transform mouse fibroblasts into a state resembling embryonic stem cells (ES cells), referred to as Induced Pluripotency. Defects in Sox2 are the cause of microphthalmia syndromic type 3. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Rabbit serum containing 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 35 kDa |
| 参考文献 |
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Sox2 antibody (pAb) tested by Western blot. HeLa cell extract expressing mouse Sox2 (50 µg per lane) probed with Sox2 antibody at a dilution of 1:5,000. |
