| 货号 | 39994 |
| 克隆类别 | AF27 |
| 同种亚型 | IgG2a |
| 反应种属 | Human, Mouse |
| 来源宿主 | Mouse |
| 应用 | ChIP |
| 使用方法 | Published Applications: ChIP See references for more information. Individual optimization may be required. This antibody has not been validated for use in Western blotting. Use 61089instead. |
| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This BMI-1 antibody was raised against a recombinant protein corresponding to full-length mouse BMI-1. |
| 背景 | BMI-1 is a member of the Polycomb PRC1 complex that is recruited to transcriptionally repressed genes subsequent to histone H3 lysine 27 methylation in order to maintain repression. In the PRC1 complex, BMI-1 is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2, resulting in the ubiquitylation of histone H2A at lysine 119. BMI-1 acts as an oncogene and cooperates with c-myc in the initiation of lymphoma. High levels of expression of BMI-1 are observed in metastatic melanoma, and BMI-1 has been implicated in several other cancers. BMI-1 is required for hematopoietic stem cell self renewal. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 40 kDa |
| 参考文献 |
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