| 货号 | 39974 |
| 克隆类别 | 4γ-7A11 |
| 同种亚型 | IgG1k |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | Western Blot/Immunohistochemistry/Electrophoretic Mobility Shift Assay |
| 使用方法 | Published Applications: IHC EMSA WB See references for more information. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This RAR-γ antibody was raised against a recombinant protein corresponding to amino acids 428-441 (F-region) of human RARγ. |
| 背景 | Retinoic acid receptors(RAR) are nuclear receptors that are activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors (RAR), RAR-α, RAR-β and RAR-γ.RAR-γ has two splice isoforms. RAR-γ heterodimerizes with RXR and in the absence of ligand, the RAR/RXR dimer binds to hormone response elements complexed with co-repressor protein. Binding of agonist ligands to RAR results in dissociation of co-repressor and recruitment of coactivator protein which in turn promotes transcription of the downstream target gene into mRNA and eventually protein. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 52 kDa |
| 参考文献 |
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