| 货号 | 39830 |
| 克隆类别 | N4.4 |
| 同种亚型 | IgG1 |
| 反应种属 | Human, Mouse |
| 来源宿主 | Mouse |
| 应用 | ChIP/Western Blot/Immunoprecipitation |
| 使用方法 | Published Applications: ChIP IP WB See references for more information. Individual optimization may be required. |
| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This MLL / HRX antibody was raised against a recombinant protein corresponding to amino acids 161-356 of mouse MLL. |
| 背景 | MLL (myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)), also known as Histone-lysine N-methyltransferase HRX, is a SET-domain containing histone methyltransferase specific for lysine 4 of histone H3. It serves as a transcriptional activator for many target genes, including several HOX genes. MLL is a frequent target for translocations in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and mixed lineage leukemia (MLL). A key feature of MLL fusion proteins is their ability to efficiently transform hematopoietic cells into leukemia stem cells. Leukemogenic MLL translocations encode MLL fusion proteins that have lost H3 Lys4 methyltransferase activity. MLL is found in a complex of proteins that includes ASH2L, WDR5, DPY30 and RBBP5. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 440 kDa |
| 参考文献 |
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