| 货号 | 39396 |
| 同种亚型 | IgG |
| 反应种属 | Human |
| 来源宿主 | Mouse |
| 应用 | Western Blot |
| 使用方法 | Validated Applications: WB: 0.5 - 2 µg/ml dilution |
| 供应商 | Active Motif |
| 纯化方式 | Protein G Chromatography |
| 免疫原 | This MALT1 antibody was raised against a recombinant protein corresponding to amino acids 701-808 of mouse MALT1. |
| 背景 | MALT1 enhances Bcl10-induced activation of NFκB and is also involved in nuclear export of Bcl10. MALT1 binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. MALT1 dependent Bcl10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. MALT1 was independently identified as a protein of 824 amino acids, and human MALT2 isoform b is an amino acid protein of 813 amino acids. MALT1 is thought to play a role in NFκB signaling by enhancing NFκB (NFκB p50 and NFκB p65) activation through interaction with Bcl10. Interaction between MALT1 and Bcl10 mediates IKK (IKKα, IKKβ Clone 10AG2, IKKβ Clone 10A9B6, IKKi/IKKε and IKKγ) activation in vitro through facilitating the ubiquitination of NEMO by the ubiquitin conjugating enzyme UBC13. |
| 运输条件 | Blue Ice |
| 存放说明 | Antibodies in solution can be stored at -20°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 存储溶液 | Purified IgG in 70 mM Tris (pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30% glycerol and 0.035% sodium azide. Sodium azide is highly toxic. |
| 计算分子量 | 92 kDa |
| 参考文献 |
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MALT1 mAb tested by Western blot. MALT1 detection by Western blot. The analysis was performed using 20 µg Jurkat nuclear extract and MALT1 mAb at a 2 µg/ml dilution. |
