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Mouse IL-13 Culture Media Quantikine SixPak (6 Plates) (1 PK)

货号: SM1300CB 基本售价: 19749.7 元 规格: 1 PACK

产品信息

概述
货号SM1300CB
描述The Quantikine Mouse IL-13 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-13 levels in cell culture supernates. It contains E. coli-expressed recombinant mouse IL-13 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse IL-13 accurately. Results obtained using natural mouse IL-13 showed dose curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-13.
别名ALRHMGC116789; BHR1interleukin-13; IL13; IL-13; IL-13MGC116788; interleukin 13; MGC116786; NC30; P600;
全称
Interleukin 13
反应种属Mouse
目标/特异性Natural and recombinant mouse IL-13
性能
供应商R&D Systems
Entrez Gene IDs
3596 (Human); 16163 (Mouse); 116553 (Rat); 574325 (Primate)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
Authors: U Fujii, N Miyahara, A Taniguchi, N Oda, D Morichika, E Murakami, H Nakayama, K Waseda, M Kataoka, H Kakuta, M Tanimoto, A Kanehiro
Respir. Res, 2017;18(1):23.
Species: Mouse
Sample Type: BALF

Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma
EBioMedicine, 2016;0(0):.
Species: Mouse
Sample Type: Tissue Homogenates

NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
Sci Rep, 2016;6(0):39075.
Species: Mouse
Sample Type: Tissue Homogenates

NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
Sci Rep, 2016;6(0):39075.
Species: Mouse
Sample Type: Tissue Homogenates

Increased mitochondrial arginine metabolism supports bioenergetics in asthma
J Clin Invest, 2016;0(0):.
Species: Mouse
Sample Type: BAL

Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase.
Authors: Mishra, Amarjit, Brown, Alexandr, Yao, Xianglan, Yang, Shutong, Park, Sung-Jun, Liu, Chengyu, Dagur, Pradeep, McCoy, J Philip, Keeran, Karen J, Nugent, Gayle Z, Jeffries, Kenneth, Qu, Xuan, Yu, Zu-Xi, Levine, Stewart, Chung, Jay H
Nat Commun, 2015;6(0):6224.
Species: Mouse
Sample Type: Cell Culture Supernates

G-protein-coupled estrogen receptor agonist suppresses airway inflammation in a mouse model of asthma through IL-10.
Authors: Itoga M, Konno Y, Moritoki Y, Saito Y, Ito W, Tamaki M, Kobayashi Y, Kayaba H, Kikuchi Y, Chihara J, Takeda M, Ueki S, Hirokawa M
PLoS ONE, 2015;10(3):e0123210.
Species: Mouse
Sample Type: BALF

PU.1 Suppresses Th2 Cytokine Expression via Silencing of GATA3 Transcription in Dendritic Cells.
Authors: Yashiro T, Kubo M, Ogawa H, Okumura K, Nishiyama C
PLoS ONE, 2015;10(9):e0137699.
Species: Mouse
Sample Type: Cell Culture Supernates

Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
Authors: Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C
J Immunol, 2014;192(8):3569-81.
Species: Mouse
Sample Type: Tissue Homogenates

Impact of ozone exposure on the response to glucocorticoid in a mouse model of asthma: involvements of p38 MAPK and MKP-1.
Authors: Bao, Aihua, Li, Feng, Zhang, Min, Chen, Yuqing, Zhang, Pengyu, Zhou, Xin
Respir Res, 2014;15(0):126.
Species: Mouse
Sample Type: BALF

Genetic vaccine for respiratory syncytial virus provides protection without disease potentiation.
Authors: Johnson T, Rangel D, Graham B, Brough D, Gall J
Mol Ther, 2014;22(1):196-205.
Species: Mouse
Sample Type: Cell Culture Supernates

Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response.
Authors: Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, Ukil A
FASEB J, 2014;28(4):1756-68.
Species: Mouse
Sample Type: Cell Culture Supernates

Induction of the specific allergic immune response is independent of proteases from the fungus Alternaria alternata.
Authors: Denis O, Vincent M, Havaux X, De Prins S, Treutens G, Huygen K
Eur J Immunol, 2013;43(4):907-17.
Species: Mouse
Sample Type: Cell Culture Supernates

Antibody to mCLCA3 suppresses symptoms in a mouse model of asthma.
Authors: Song L, Liu D, Wu C, Wu S, Yang J, Ren F, Li Y
PLoS ONE, 2013;8(12):e82367.
Species: Mouse
Sample Type: BALF

Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2.
Authors: Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
Am. J. Pathol., 2012;179(1):302-14.
Species: Mouse
Sample Type: Tissue Homogenates

Monocyte-derived dendritic cell recruitment and allergic T(H)2 responses after exposure to diesel particles are CCR2 dependent.
Authors: Provoost S, Maes T, Joos GF, Tournoy KG
J. Allergy Clin. Immunol., 2012;129(2):483-91.
Species: Mouse
Sample Type: BALF

Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor.
J. Exp. Med., 2012;209(8):1493-503.
Species: Mouse
Sample Type: Cell Culture Supernates

TLR-mediated distinct IFN-gamma/IL-10 pattern induces protective immunity against murine visceral leishmaniasis.
Eur. J. Immunol., 2012;42(8):2087-99.
Species: Mouse
Sample Type: Cell Culture Supernates

Reciprocal expression of IL-25 and IL-17A is important for allergic airways hyperreactivity.
Authors: Barlow JL, Flynn RJ, Ballantyne SJ, McKenzie AN
Clin. Exp. Allergy, 2011;41(10):1447-55.
Species: Mouse
Sample Type: BALF

Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma.
Authors: Hirata H, Arima M, Fukushima Y, Honda K, Sugiyama K, Tokuhisa T, Fukuda T
Clin. Exp. Allergy, 2011;41(8):1133-42.
Species: Mouse
Sample Type: BALF

The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling.
Authors: Doherty TA, Soroosh P, Khorram N, Fukuyama S, Rosenthal P, Cho JY, Norris PS, Choi H, Scheu S, Pfeffer K, Zuraw BL, Ware CF, Broide DH, Croft M
Nat. Med., 2011;17(5):596-603.
Species: Mouse
Sample Type: Tissue Homogenates

IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
J. Immunol., 2011;188(3):1503-13.
Species: Mouse
Sample Type: BALF

The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines.
Authors: Vultaggio A, Nencini F, Pratesi S, Maggi L, Guarna A, Annunziato F, Romagnani S, Parronchi P, Maggi E
J. Immunol., 2011;186(8):4707-15.
Species: Mouse
Sample Type: Serum

Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts.
Authors: Asquith KL, Horvat JC, Kaiko GE
PLoS Pathog., 2011;7(5):e1001339.
Species: Mouse
Sample Type: Cell Culture Supernates

IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease.
Authors: Taube C, Tertilt C, Gyulveszi G, Dehzad N, Kreymborg K, Schneeweiss K, Michel E, Reuter S, Renauld JC, Arnold-Schild D, Schild H, Buhl R, Becher B
PLoS ONE, 2011;6(7):e21799.
Species: Mouse
Sample Type: BALF

IL-33-activated dendritic cells are critical for allergic airway inflammation.
Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
Eur. J. Immunol., 2011;41(6):1675-86.
Species: Mouse
Sample Type: BALF

Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.
Authors: Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K
Immunol. Lett., 2011;136(2):194-202.
Species: Mouse
Sample Type: Plasma

Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
Authors: Louten J, Rankin AL, Li Y
Int. Immunol., 2011;23(5):307-15.
Species: Mouse
Sample Type: BALF

House dust mite induces direct airway inflammation in vivo: implications for future disease therapy?
Authors: De Alba J, Raemdonck K, Dekkak A, Collins M, Wong S, Nials AT, Knowles RG, Belvisi MG, Birrell MA
Eur. Respir. J., 2010;35(6):1377-87.
Species: Mouse
Sample Type: BALF

Mucosal vaccination using claudin-4-targeting.
Authors: Kakutani H, Kondoh M, Fukasaka M, Suzuki H, Hamakubo T, Yagi K
Biomaterials, 2010;31(20):5463-71.
Species: Mouse
Sample Type: Serum

Anti-Asthma Simplified Herbal Medicine Intervention-induced long-lasting tolerance to allergen exposure in an asthma model is interferon-gamma, but not transforming growth factor-beta dependent.
Authors: Srivastava K, Zhang T, Yang N, Sampson H, Li XM
Clin. Exp. Allergy, 2010;40(11):1678-88.
Species: Mouse
Sample Type: BALF

Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling.
Authors: Graham BB, Mentink-Kane MM, El-Haddad H
Am. J. Pathol., 2010;177(3):1549-61.
Species: Mouse
Sample Type: Tissue Homogenates

Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation.
Authors: Wright PL, Yu J, Di YP
J. Exp. Med., 2010;207(12):2595-607.
Species: Mouse
Sample Type: BALF

Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice.
Authors: Alm AS, Li K, Yang D, Andersson R, Lu Y, Wang X
Cytokine, 2010;49(3):256-63.
Species: Mouse
Sample Type: BALF

Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
Authors: Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN
Nature, 2010;464(7293):1367-70.
Species: Mouse
Sample Type: Cell Culture Supernates

The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.
Authors: Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U
J. Immunol., 2009;182(3):1617-30.
Species: Mouse
Sample Type: Cell Culture Supernates

Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.
Authors: Mizutani N, Nabe T, Yoshino S
J. Immunol., 2009;183(6):4039-46.
Species: Mouse
Sample Type: BALF

Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner.
Authors: Kottyan LC, Collier AR, Cao KH, Niese KA, Hedgebeth M, Radu CG, Witte ON, Khurana Hershey GK, Rothenberg ME, Zimmermann N
Blood, 2009;114(13):2774-82.
Species: Mouse
Sample Type: Cell Lysates

Celastrol suppresses allergen-induced airway inflammation in a mouse allergic asthma model.
Authors: Kim DY, Park JW, Jeoung D, Ro JY
Eur. J. Pharmacol., 2009;612(1):98-105.
Species: Mouse
Sample Type: BALF

A TLR2 agonist in German cockroach frass activates MMP-9 release and is protective against allergic inflammation in mice.
Authors: Page K, Ledford JR, Zhou P, Wills-Karp M
J. Immunol., 2009;183(5):3400-8.
Species: Mouse
Sample Type: Tissue Homogenates

Osteopontin deficiency protects against airway remodeling and hyperresponsiveness in chronic asthma.
Authors: Simoes DC, Xanthou G, Petrochilou K, Panoutsakopoulou V, Roussos C, Gratziou C
Am. J. Respir. Crit. Care Med., 2009;179(10):894-902.
Species: Mouse
Sample Type: Tissue Homogenates

Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis.
Authors: Izumo T, Kondo M, Nagai A
Eur. Respir. J., 2009;34(6):1444-51.
Species: Mouse
Sample Type: BALF

A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice.
Authors: Shinagawa K, Ploplis VA, Castellino FJ
Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(5):L763-70.
Species: Mouse
Sample Type: BALF

Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7.
Authors: Vultaggio A, Nencini F, Fitch PM, Fili L, Maggi L, Fanti P, deVries A, Beccastrini E, Palandri F, Manuelli C, Bani D, Giudizi MG, Guarna A, Annunziato F, Romagnani S, Maggi E, Howie SE, Parronchi P
J. Immunol., 2009;182(2):880-9.
Species: Mouse
Sample Type: Cell Culture Supernates

Intranasal challenge with increasing ovalbumin doses differently affects airway hyperresponsiveness and inflammatory cell accumulation in mouse model of asthma.
Authors: Bosnjak B, Ivetic Tkalcevic V, Duric K, Belamaric D, Cuzic S, Ferencic Z, Brajsa K, Glojnaric I, Antolovic R, Hrvacic B
Inflamm. Res., 2009;58(11):773-81.
Species: Mouse
Sample Type: BALF

Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma.
Authors: Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF, Wong BA, Bonner JC
Am. J. Respir. Cell Mol. Biol., 2009;40(3):349-58.
Species: Mouse
Sample Type: BALF

Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation.
Authors: Park SJ, Lee KS, Kim SR, Min KH, Choe YH, Moon H, Chae HJ, Yoo WH, Lee YC
J. Immunol., 2009;183(5):3259-67.
Species: Mouse
Sample Type: BALF

Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production.
Authors: Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD
Inflamm. Res., 2009;58(12):845-54.
Species: Mouse
Sample Type: BALF

Temporal changes in myeloid cells in the cervix during pregnancy and parturition.
Authors: Timmons BC, Fairhurst AM, Mahendroo MS
J. Immunol., 2009;182(5):2700-7.
Species: Mouse
Sample Type: Tissue Homogenates

Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment.
Authors: Park SK, Cho MK, Park HK, Lee KH, Lee SJ, Choi SH, Ock MS, Jeong HJ, Lee MH, Yu HS
J. Immunol., 2009;182(11):6907-14.
Species: Mouse
Sample Type: BALF

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
Authors: He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS
J. Allergy Clin. Immunol., 2009;124(4):761-70.e1.
Species: Mouse
Sample Type: Cell Culture Supernates

TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity.
Authors: Johnson TR, Rao S, Seder RA, Chen M, Graham BS
Vaccine, 2009;27(23):3045-52.
Species: Mouse
Sample Type: Cell Culture Supernates

Lovastatin inhibits antigen-induced airway eosinophilia without affecting the production of inflammatory mediators in mice.
Authors: Chiba Y, Sato S, Misawa M
Inflamm. Res., 2009;0(0):.
Species: Mouse
Sample Type: BALF

Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses.
Authors: Zhou W, Newcomb DC, Moore ML, Goleniewska K, ONeal JF, Peebles RS
J. Immunol., 2008;181(8):5360-7.
Species: Mouse
Sample Type: Tissue Homogenates

Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity.
Authors: Presser K, Schwinge D, Wegmann M, Huber S, Schmitt S, Quaas A, Maxeiner JH, Finotto S, Lohse AW, Blessing M, Schramm C
J. Immunol., 2008;181(11):7751-8.
Species: Mouse
Sample Type: BALF

IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
Authors: Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA
J. Immunol., 2008;180(1):522-9.
Species: Mouse
Sample Type: BALF

Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
J. Immunol., 2008;181(2):1491-8.
Species: Mouse
Sample Type: Cell Culture Supernates

CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling.
Authors: Kearley J, Robinson DS, Lloyd CM
J. Allergy Clin. Immunol., 2008;122(3):617-24.e6.
Species: Mouse
Sample Type: BALF

Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.
Authors: Therien AG, Bernier V, Weicker S, Tawa P, Falgueyret JP, Mathieu MC, Honsberger J, Pomerleau V, Robichaud A, Stocco R, Dufresne L, Houshyar H, Lafleur J, Ramachandran C, ONeill GP, Slipetz D, Tan CM
Am. J. Respir. Cell Mol. Biol., 2008;39(1):26-35.
Species: Mouse
Sample Type: BALF

GS143, an IkappaB ubiquitination inhibitor, inhibits allergic airway inflammation in mice.
Authors: Hirose K, Wakashin H, Oki M, Kagami S, Suto A, Ikeda K, Watanabe N, Iwamoto I, Furuichi Y, Nakajima H
Biochem. Biophys. Res. Commun., 2008;374(3):507-11.
Species: Mouse
Sample Type: Cell Culture Supernates

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells.
Authors: Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ
J. Exp. Med., 2008;205(3):699-710.
Species: Mouse
Sample Type: BALF

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance.
Authors: Pesu M, Watford WT, Wei L, Xu L, Fuss I, Strober W, Andersson J, Shevach EM, Quezado M, Bouladoux N, Roebroek A, Belkaid Y, Creemers J, OShea JJ
Nature, 2008;455(7210):246-50.
Species: Mouse
Sample Type: Cell Culture Supernates

Ecto-5-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis.
Authors: Peng Z, Fernandez P, Wilder T, Yee H, Chiriboga L, Chan ES, Cronstein BN
FASEB J., 2008;22(7):2263-72.
Species: Mouse
Sample Type: Tissue Homogenates

A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis.
Authors: Trujillo G, OConnor EC, Kunkel SL, Hogaboam CM
Am. J. Pathol., 2008;172(5):1209-21.
Species: Mouse
Sample Type: Tissue Homogenates

CD43 regulates Th2 differentiation and inflammation.
Authors: Cannon JL, Collins A, Mody PD, Balachandran D, Henriksen KJ, Smith CE, Tong J, Clay BS, Miller SD, Sperling AI
J. Immunol., 2008;180(11):7385-93.
Species: Mouse
Sample Type: Cell Culture Supernates

Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.
Authors: Johnson TR, Rothenberg ME, Graham BS
J. Leukoc. Biol., 2008;84(3):748-59.
Species: Mouse
Sample Type: Tissue Homogenates

Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
Eur. J. Pharmacol., 2008;590(1):400-8.
Species: Mouse
Sample Type: Tissue Homogenates

Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function.
Authors: Pan PY, Wang GX, Yin B, Ozao J, Ku T, Divino CM, Chen SH
Blood, 2007;111(1):219-28.
Species: Mouse
Sample Type: Cell Culture Supernates

FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Authors: Daniel C, Sartory NA, Zahn N
Mol. Immunol., 2007;44(13):3305-16.
Species: Mouse
Sample Type: Cell Culture Supernates

The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia.
Authors: Kudlacz E, Conklyn M, Andresen C, Whitney-Pickett C, Changelian P
Eur. J. Pharmacol., 2007;582(1):154-61.
Species: Mouse
Sample Type: BALF

Src homology 2 domain-containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung.
Authors: Oh SY, Zheng T, Bailey ML, Barber DL, Schroeder JT, Kim YK, Zhu Z
J. Allergy Clin. Immunol., 2007;119(1):123-31.
Species: Mouse
Sample Type: BALF

Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness.
Authors: Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, Israel E, Haley KJ, Serhan CN
J. Immunol., 2007;178(1):496-502.
Species: Mouse
Sample Type: BALF

Prolonged inhaled allergen exposure can induce persistent tolerance.
Authors: Van Hove CL, Maes T, Joos GF, Tournoy KG
Am. J. Respir. Cell Mol. Biol., 2007;36(5):573-84.
Species: Mouse
Sample Type: Cell Culture Supernates

B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma.
Authors: Matsumoto K, Fukuyama S, Eguchi-Tsuda M, Nakano T, Matsumoto T, Matsumura M, Moriwaki A, Kan-o K, Wada Y, Yagita H, Shin T, Pardoll DM, Patcharee R, Azuma M, Nakanishi Y, Inoue H
Biochem. Biophys. Res. Commun., 2007;365(1):170-5.
Species: Mouse
Sample Type: BALF

IL-27 suppresses Th2 cell development and Th2 cytokines production from polarized Th2 cells: a novel therapeutic way for Th2-mediated allergic inflammation.
Authors: Yoshimoto T, Yoshimoto T, Yasuda K, Mizuguchi J, Nakanishi K
J. Immunol., 2007;179(7):4415-23.
Species: Mouse
Sample Type: Serum

Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma.
Authors: Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR
J. Immunol., 2007;178(10):6191-9.
Species: Mouse
Sample Type: BALF

T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
J. Allergy Clin. Immunol., 2007;119(3):662-70.
Species: Mouse
Sample Type: BALF

Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling.
Authors: Denis O, van den Brule S, Heymans J, Havaux X, Rochard C, Huaux F, Huygen K
Immunology, 2007;122(2):268-78.
Species: Mouse
Sample Type: BALF

Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation.
Authors: Kitamura K, Takeda K, Koya T, Miyahara N, Kodama T, Dakhama A, Takai T, Hirano A, Tanimoto M, Harada M, Gelfand EW
J. Immunol., 2007;178(1):480-8.
Species: Mouse
Sample Type: BALF

Developmental differences in the responses of IL-6 and IL-13 transgenic mice exposed to hyperoxia.
Authors: Choo-Wing R, Nedrelow JH, Homer RJ, Elias JA, Bhandari V
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L142-50.
Species: Mouse
Sample Type: Cell Lysates

Obligatory role for interleukin-13 in obstructive lesion development in airway allografts.
Authors: Lama VN, Harada H, Badri LN, Flint A, Hogaboam CM, McKenzie A, Martinez FJ, Toews GB, Moore BB, Pinsky DJ
Am. J. Pathol., 2006;169(1):47-60.
Species: Mouse
Sample Type: Tissue Homogenates

Persistent effects induced by IL-13 in the lung.
Authors: Fulkerson PC, Fischetti CA, Hassman LM, Nikolaidis NM, Rothenberg ME
Am. J. Respir. Cell Mol. Biol., 2006;35(3):337-46.
Species: Mouse
Sample Type: BALF

Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues.
Authors: Alvarez D, Swirski FK, Yang TC, Fattouh R, Croitoru K, Bramson JL, Stampfli MR, Jordana M
J. Immunol., 2006;176(4):2568-80.
Species: Mouse
Sample Type: Serum

Modulation of airway remodeling and airway inflammation by peroxisome proliferator-activated receptor gamma in a murine model of toluene diisocyanate-induced asthma.
Authors: Lee KS, Park SJ, Kim SR, Min KH, Jin SM, Lee HK, Lee YC
J. Immunol., 2006;177(8):5248-57.
Species: Mouse
Sample Type: BALF

Allergic airway inflammation inhibits pulmonary antibacterial host defense.
Authors: Beisswenger C, Kandler K, Hess C, Garn H, Felgentreff K, Wegmann M, Renz H, Vogelmeier C, Bals R
J. Immunol., 2006;177(3):1833-7.
Species: Mouse
Sample Type: BALF

Experimental gastrointestinal allergy enhances pulmonary responses to specific and unrelated allergens.
Authors: Brandt EB, Scribner TA, Akei HS, Rothenberg ME
J. Allergy Clin. Immunol., 2006;118(2):420-7.
Species: Mouse
Sample Type: BALF

Intranasal mite allergen induces allergic asthma-like responses in NC/Nga mice.
Authors: Shibamori M, Ogino K, Kambayashi Y, Ishiyama H
Life Sci., 2005;78(9):987-94.
Species: Mouse
Sample Type: BALF

MyD88-dependent induction of allergic Th2 responses to intranasal antigen.
Authors: Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K
J. Clin. Invest., 2005;115(2):459-67.
Species: Human
Sample Type: Cell Culture Supernates

Inhaled p38alpha mitogen-activated protein kinase antisense oligonucleotide attenuates asthma in mice.
Authors: Duan W, Chan JH, McKay K, Crosby JR, Choo HH, Leung BP, Karras JG, Wong WS
Am. J. Respir. Crit. Care Med., 2005;171(6):571-8.
Species: Mouse
Sample Type: BALF

Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice.
Authors: Leino MS, Alenius HT, Fyhrquist-Vanni N, Wolff HJ, Reijula KE, Hintikka EL, Salkinoja-Salonen MS, Haahtela T, Mäkelä MJ
Am. J. Respir. Crit. Care Med., 2005;173(5):512-8.
Species: Mouse
Sample Type: BALF

Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma.
Authors: Virag L, Bai P, Bak I, Pacher P, Mabley JG, Liaudet L, Bakondi E, Gergely P, Kollai M, Szabo C
Med. Sci. Monit., 2004;10(3):BR77-83.
Species: Mouse
Sample Type: BALF

Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV.
Authors: Johnson TR, Varga SM, Braciale TJ, Graham BS
J. Virol., 2004;78(16):8753-60.
Species: Mouse
Sample Type: Tissue Homogenates

Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice.
Authors: Kobayashi T, Iijima K, Kita H
J. Immunol., 2003;170(11):5756-63.
Species: Mouse
Sample Type: BALF

MHC class II-associated invariant chain isoforms regulate pulmonary immune responses.
Authors: Ye Q, Finn PW, Sweeney R, Bikoff EK, Riese RJ
J. Immunol., 2003;170(3):1473-80.
Species: Mouse
Sample Type: BALF

Dual roles of IL-4 in lung injury and fibrosis.
Authors: Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH
J. Immunol., 2003;170(4):2083-92.
Species: Mouse
Sample Type: Serum

Interleukin-9 induces mucous cell metaplasia independent of inflammation.
Authors: Reader JR, Hyde DM, Schelegle ES, Aldrich MC, Stoddard AM, McLane MP, Levitt RC, Tepper JS
Am. J. Respir. Cell Mol. Biol., 2003;28(6):664-72.
Species: Mouse
Sample Type: BALF

IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen.
Authors: Herrick CA, Xu L, McKenzie AN, Tigelaar RE, Bottomly K
J. Immunol., 2003;170(5):2488-95.
Species: Mouse
Sample Type: Cell Culture Supernates

Persistence of bronchopulmonary hyper-reactivity and eosinophilic lung inflammation after anti-IL-5 or -IL-13 treatment in allergic BALB/c and IL-4Ralpha knockout mice.
Authors: Proust B, Nahori MA, Ruffie C, Lefort J, Vargaftig BB
Clin. Exp. Allergy, 2003;33(1):119-31.
Species: Mouse
Sample Type: BALF

IFN-gamma, but not Fas, mediates reduction of allergen-induced mucous cell metaplasia by inducing apoptosis.
Authors: Shi ZO, Fischer MJ, De Sanctis GT, Schuyler MR, Tesfaigzi Y
J. Immunol., 2002;168(9):4764-71.
Species: Mouse
Sample Type: BALF

Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy.
Authors: Drouin SM, Corry DB, Hollman TJ, Kildsgaard J, Wetsel RA
J. Immunol., 2002;169(10):5926-33.
Species: Mouse
Sample Type: BALF

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景IL-13 (Interleukin-13) plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances by macrophages, fibroblasts, and endothelial cells. It promotes B cell activation, immunoglobulin class switching to IgE, and the upregulation of CD23/Fc epsilon RII. IL-13 signals through a receptor complex containing IL-13 R alpha 1 and IL-4 R alpha. This complex also functions as the type 2 IL-4 receptor. IL-13 R alpha 2 binds IL-13 and prevents IL-13 from signaling through the IL-13 R alpha 1/IL-4 R alpha complex. IL-13-bound IL-13 R alpha 2 can directly promote tumor cell invasiveness and the development of tissue fibrosis.
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参考文献
  • Cytokines and Receptors in Allergy and Asthma
  • Cytokines and Receptors in Angiogenesis
  • Cytokines and Receptors in Tfh Cell Differentiation and Function
  • gamma delta T Cells
  • Group 2 ILCs
  • Myeloid-derived Suppressor Cells (MDSC)
  • Natural Killer T (NKT) Cells
  • T Cell Cytokine Signaling
  • Th2 Cells
  • Th22 Cells