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Mouse CXCL12/SDF-1 alpha Quantikine ELISA Kit (1 KT)

货号: MCX120 基本售价: 6791.4 元 规格: 1 Kit

产品信息

概述
货号MCX120
描述The Quantikine Mouse SDF-1 alpha Immunoassay is a 4.5 hour solid-phase ELISA designed to measure mouse SDF-1 alpha in cell culture supernates and mouse serum. It contains E. coli-expressed recombinant mouse SDF-1 alpha and antibodies raised against the recombinant factor. It has been shown to accurately quantitate recombinant mouse SDF-1 alpha. Results obtained using natural SDF-1 alpha showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values of natural mouse SDF-1 alpha.
别名CXCL12 chemokine (C-X-C motif) ligand 12; IRH; PBSF; SCYB12; SDF1; SDF1A; SDF1B; TLSF; TPAR1;
反应种属Mouse
目标/特异性Natural and recombinant mouse SDF-1 alpha
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
6387 (Human); 20315 (Mouse); 493806 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Absence of CCR2 results in an inflammaging environment in young mice with age-independent impairments in muscle regeneration
J Leukoc Biol, 2016;0(0):.
Species: Mouse
Sample Type: Tissue Homogenates

Direct Renin Inhibition with Aliskiren Improves Ischemia-Induced Neovasculogenesis in Diabetic Animals via the SDF-1 Related Mechanism.
Authors: Chang T, Wu T, Huang P, Lin C, Chen J, Lin L, Lin S, Chen J
PLoS ONE, 2015;10(8):e0136627.
Species: Mouse
Sample Type: Plasma

Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms.
Authors: Toyoshima A, Yasuhara T, Kameda M, Morimoto J, Takeuchi H, Wang F, Sasaki T, Sasada S, Shinko A, Wakamori T, Okazaki M, Kondo A, Agari T, Borlongan C, Date I
PLoS ONE, 2015;10(6):e0127302.
Species: Rat
Sample Type: Tissue Homogenates

SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging.
Authors: Iyer S, Brooks R, Gumbleton M, Kerr W
Stem Cells Dev, 2015;24(9):1073-81.
Species: Mouse
Sample Type: Serum

Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays.
Authors: Shen K, Luk S, Hicks D, Elman J, Bohr S, Iwamoto Y, Murray R, Pena K, Wang F, Seker E, Weissleder R, Yarmush M, Toner M, Sgroi D, Parekkadan B
Nat Commun, 2014;5(0):5662.
Species: Mouse
Sample Type: Tissue Lysate

C/EBPbeta mediates osteoclast recruitment by regulating endothelial progenitor cell expression of SDF-1alpha.
Authors: Fu S, Pang H, Xu J, Wu X
PLoS ONE, 2014;9(3):e91217.
Species: Mouse
Sample Type: cell supernates

The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization.
Authors: Hoellenriegel J, Zboralski D, Maasch C, Rosin N, Wierda W, Keating M, Kruschinski A, Burger J
Blood, 2014;123(7):1032-9.
Species: Mouse
Sample Type: cell supernates

CCAAT/enhancer-binding protein beta expressed by bone marrow mesenchymal stromal cells regulates early B-cell lymphopoiesis.
Authors: Yoshioka S, Miura Y, Yao H, Satake S, Hayashi Y, Tamura A, Hishita T, Ichinohe T, Hirai H, Takaor-Kondo A, Maekawa T
Stem Cells, 2014;32(3):730-40.
Species: Mouse
Sample Type: cell supernates

Klotho deficiency disrupts hematopoietic stem cell development and erythropoiesis.
Authors: Vadakke Madathil S, Coe L, Casu C, Sitara D
Am J Pathol, 2014;184(3):827-41.
Species: Mouse
Sample Type: Serum

Heparan sulfate inhibits hematopoietic stem and progenitor cell migration and engraftment in mucopolysaccharidosis I.
Authors: Watson H, Holley R, Langford-Smith K, Wilkinson F, van Kuppevelt T, Wynn R, Wraith J, Merry C, Bigger B
J Biol Chem, 2014;289(52):36194-203.
Species: Mouse
Sample Type: BM soluble fraction

Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis.
Authors: Shu, Hui-Kuo, Yoon, Younghyo, Hong, Samuel, Xu, Kaiming, Gao, Huiying, Hao, Chunhai, Torres-Gonzalez, Edilson, Nayra, Cardenes, Rojas, Mauricio, Shim, Hyunsuk
PLoS ONE, 2013;8(11):e79768.
Species: Mouse
Sample Type: BALF

Protective effects of mesenchymal stem cells with CXCR4 up-regulation in a rat renal transplantation model.
Authors: Cao, Zhiqiang, Zhang, Geng, Wang, Fuli, Liu, Hongbao, Liu, Long, Han, Yaling, Zhang, Jian, Yuan, Jianlin
PLoS ONE, 2013;8(12):e82949.
Species: Mouse
Sample Type: Homogenized Tissue

Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production.
Authors: Fukuda H, Mochizuki S, Abe H, Okano HJ, Hara-Miyauchi C, Okano H, Yamaguchi N, Nakayama M, DArmiento J, Okada Y
Br. J. Cancer, 2011;105(10):1615-24.
Species: Mouse
Sample Type: Serum

JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow.
Authors: Arcangeli ML, Frontera V, Bardin F, Obrados E, Adams S, Chabannon C, Schiff C, Mancini SJ, Adams RH, Aurrand-Lions M
Blood, 2011;118(17):4609-19.
Species: Mouse
Sample Type: Cell Culture Supernates

Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence.
Authors: Oladipupo SS, Hu S, Santeford AC, Yao J, Kovalski JR, Shohet RV, Maslov K, Wang LV, Arbeit JM
Blood, 2011;117(15):4142-53.
Species: Human
Sample Type: Plasma

Application of the chemokine CXCL12 expression plasmid restores wound healing to near normal in a diabetic mouse model.
Authors: Restivo TE, Mace KA, Harken AH, Young DM
J Trauma, 2010;69(2):392-8.
Species: Mouse
Sample Type: Serum

CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1.
Authors: Kollmar O, Rupertus K, Scheuer C, Nickels RM, Haberl GC, Tilton B, Menger MD, Schilling MK
Int. J. Cancer, 2010;126(6):1302-15.
Species: Mouse
Sample Type: Serum

Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex.
Authors: Ratajczak MZ, Lee H, Wysoczynski M, Wan W, Marlicz W, Laughlin MJ, Kucia M, Janowska-Wieczorek A, Ratajczak J
Leukemia, 2010;24(5):976-85.
Species: Mouse
Sample Type: Plasma

Rosuvastatin reduces atherosclerotic lesions and promotes progenitor cell mobilisation and recruitment in apolipoprotein E knockout mice.
Authors: Schroeter MR, Humboldt T, Schafer K, Konstantinides S
Atherosclerosis, 2009;205(1):63-73.
Species: Mouse
Sample Type: Plasma

Cell-nonautonomous function of Id1 in the hematopoietic progenitor cell niche.
Authors: Suh HC, Ji M, Gooya J, Lee M, Klarmann KD, Keller JR
Blood, 2009;114(6):1186-95.
Species: Mouse
Sample Type: Serum

Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction.
Authors: Zaruba MM, Theiss HD, Vallaster M, Mehl U, Brunner S, David R, Fischer R, Krieg L, Hirsch E, Huber B, Nathan P, Israel L, Imhof A, Herbach N, Assmann G, Wanke R, Mueller-Hoecker J, Steinbeck G, Franz WM
Cell Stem Cell, 2009;4(4):313-23.
Species: Mouse
Sample Type: Tissue Homogenates

Endothelial nitric oxide synthase promotes bone marrow stromal cell migration to the ischemic myocardium via upregulation of stromal cell-derived factor-1alpha.
Authors: Li N, Lu X, Zhao X, Xiang FL, Xenocostas A, Karmazyn M, Feng Q
Stem Cells, 2009;27(4):961-70.
Species: Mouse
Sample Type: Tissue Homogenates

Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.
Authors: Sayyed SG, Hagele H, Kulkarni OP, Endlich K, Segerer S, Eulberg D, Klussmann S, Anders HJ
Diabetologia, 2009;52(11):2445-54.
Species: Mouse
Sample Type: Plasma

Heme oxygenase-1 promotes neovascularization in ischemic heart by coinduction of VEGF and SDF-1.
Authors: Lin HH, Chen YH, Chang PF, Lee YT, Yet SF, Chau LY
J. Mol. Cell. Cardiol., 2008;45(1):44-55.
Species: Mouse
Sample Type: Tissue Homogenates

Altered SDF-1/CXCR4 axis in patients with primary myelofibrosis and in the Gata1 low mouse model of the disease.
Authors: Migliaccio AR, Martelli F, Verrucci M, Migliaccio G, Vannucchi AM, Ni H, Xu M, Jiang Y, Nakamoto B, Papayannopoulou T, Hoffman R
Exp. Hematol., 2008;36(2):158-71.
Species: Mouse
Sample Type: Plasma

The angiogenic response is dictated by beta3 integrin on bone marrow-derived cells.
Authors: Feng W, McCabe NP, Mahabeleshwar GH, Somanath PR, Phillips DR, Byzova TV
J. Cell Biol., 2008;183(6):1145-57.
Species: Mouse
Sample Type: Plasma

Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
Eur. J. Pharmacol., 2008;590(1):400-8.
Species: Mouse
Sample Type: Tissue Homogenates

Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.
Authors: Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, Daenen LG, Man S, Xu P, Emmenegger U, Tang T, Zhu Z, Witte L, Strieter RM, Bertolini F, Voest EE, Benezra R, Kerbel RS
Cancer Cell, 2008;14(3):263-73.
Species: Mouse
Sample Type: Plasma

Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy.
Authors: Ebos JM, Lee CR, Christensen JG, Mutsaers AJ, Kerbel RS
Proc. Natl. Acad. Sci. U.S.A., 2007;104(43):17069-74.
Species: Mouse
Sample Type: Plasma

Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
Authors: Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT
J. Immunol., 2007;178(12):8148-57.
Species: Mouse
Sample Type: BALF

Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system.
Authors: Wang CH, Verma S, Hsieh IC, Chen YJ, Kuo LT, Yang NI, Wang SY, Wu MY, Hsu CM, Cheng CW, Cherng WJ
J. Mol. Cell. Cardiol., 2006;41(1):34-43.
Species: Mouse
Sample Type: Plasma

Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2.
Authors: Yamaji-Kegan K, Su Q, Angelini DJ, Champion HC, Johns RA
Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(6):L1159-68.
Species: Mouse
Sample Type: Cell Culture Supernates

Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation.
Authors: Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Chieco-Bianchi L, Amadori A
Blood, 2005;105(3):931-9.
Species: Mouse
Sample Type: Peritoneal Lavage

Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.
Authors: Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MA, Werb Z, Rafii S
Cell, 2002;109(5):625-37.
Species: Mouse
Sample Type: Plasma

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景CXCL12/Stromal Cell-derived Factor 1 (SDF-1) is a member of the CXC chemokine ligand superfamily. Six alternatively spliced CXCL12/SDF-1 isoforms have been identified including, CXCL12/SDF-1 alpha, CXCL12/SDF-1 beta, and CXCL12/SDF-1 gamma. CXCL12/SDF-1 alpha is 89 amino acids (aa) in length with a predicted molecular weight of 10 kDa, CXCL12/SDF-1 beta is 93 aa in length with a predicted molecular weight of 10.6 kDa, and CXCL12/SDF-1 gamma is 119 aa in length with a predicted molecular weight of 13.7 kDa. The mouse CXCL12/SDF-1 orthologs share 99% aa sequence identity with the human protein. The alpha and beta isoforms are ubiquitously expressed while the gamma isoform is primarily expressed in the heart. CXCL12/SDF-1 isoforms are chemotactic for T lymphocytes and monocytes. It is cardio protective and has also been shown to hinder CXCR4-mediated HIV infection of T cells.
运输条件Blue Ice
存放说明4℃
参考文献
  • A novel role for the nervous system in HSPS mobilization
  • B Cell Chemotaxis, Migration, and Adhesion
  • Chemokines and Receptors
  • CXC Chemokines and Receptors
  • Hepatic Endoderm
  • Infectious Diseases
  • Mini-review: Chemokines I
  • Mini-review: Chemokines III
  • Neuroinflammation
  • SDF-1 Effect on Hematopoietic Progenitor and Stem Cell Mobilization
  • SDF-1 in Hematopoiesis