一抗

克隆类型
多抗单抗
产品类型
标签抗体磷酸化抗体内参抗体甲基化抗体乙酰化抗体药物与化合物抗体植物抗体
研究领域
肿瘤心血管细胞生物免疫学发育生物学染色质和核信号微生物学细胞凋亡信号转导干细胞神经生物学生长因子和激素糖尿病内分泌病转运蛋白植物细菌及病毒转录调节因子海洋生物上皮细胞趋化因子结合蛋白细胞表面分子G蛋白偶联受体胶原蛋白糖蛋白交换蛋白细胞分化血管内皮细胞细胞类型标志物内皮细胞淋巴细胞T-淋巴细胞B-淋巴细胞细胞粘附分子肿瘤细胞生物标志物骨髓细胞细胞骨架跨膜蛋白细胞因子自然杀伤细胞树突状细胞标志物脂蛋白新陈代谢锌指蛋白通道蛋白细胞周期蛋白激酶和磷酸酶昆虫线粒体环指蛋白细胞自噬细胞膜受体药物及化合物泛素干扰素G蛋白信号细胞膜蛋白Alzheimers表观遗传学细胞外基质合成与降解

标记一抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

二抗

克隆类型
多抗单抗
产品分类
二抗二抗血清

标记二抗

标记类型
HRPBiotinGoldRBITCAPFITCCy3Cy5Cy5.5Cy7PEPE-Cy3PE-Cy5PE-Cy5.5PE-Cy7APCAlexa Fluor 350Alexa Fluor 488Alexa Fluor 555Alexa Fluor 594Alexa Fluor 647

蛋白质与多肽

产品分类
蛋白质多肽

标记蛋白质与多肽

所有产品
全部标记蛋白质与多肽

正常动物血清及免疫球蛋白

产品分类
正常动物血清免疫球蛋白

试剂盒

产品分类
ELISA试剂盒

常用试剂

产品分类
免疫组化常用试剂免疫印迹常用试剂常用显色试剂细胞生物学试剂分子生物学生化试剂

亲和层析柱

所有产品
亲和层析柱

配套试剂

所有产品
常用配套试剂

ELISA试剂盒

人ELISA试剂盒 大鼠ELISA试剂盒 小鼠ELISA试剂盒 牛ELISA试剂盒 鸡ELISA试剂盒 植物ELISA试剂盒 猴ELISA试剂盒 猪ELISA试剂盒 山羊ELISA试剂盒 马ELISA试剂盒 仓鼠ELISA试剂盒 绵羊ELISA试剂盒 兔子ELISA试剂盒 犬ELISA试剂盒 豚鼠ELISA试剂盒 其他ELISA试剂盒

生化试剂

色素类 分离材料及耗材 维生素 染色剂 碳水化合物 植物激素及核酸 抗生素 蛋白质 氨基酸 测试盒 其他生物试剂 缓冲剂 表面活性剂

血浆

血浆

血清

Sigma胎牛血清 gibco胎牛血清 Hyclone血清 人血清 国产新生牛血清 国产胎牛血清 其他血清

细胞

其它细胞 仓鼠细胞 猴细胞 大鼠细胞 人细胞 狗细胞 小鼠细胞 猫细胞 鸡细胞

标准品

对照品 农药标准品 标准物质 食品 无机溶液标准物质 有机溶液标准物质

抗体

兔抗 鼠抗 IgY抗体 IgA抗体 IgG抗体 二抗 一抗

裂解血

裂解血

培养基

美国药典培养基 化妆品检验培养基 大肠杆菌、大肠菌群 金黄色葡萄球菌检验 消毒灭菌效果评价 临床检验用培养基 中华人民共和国药典 欧洲药典(EP) 饮用天然矿泉水检验方法 微生物检验 霉菌、酵母菌 肠球菌、链球菌 沙门氏菌、志贺氏菌 弧菌 弯曲杆菌 李斯特氏菌 产气荚膜梭菌 阪崎肠杆菌 乳酸菌、双歧杆菌 小肠结肠炎耶尔森氏菌 蜡样芽孢杆菌检验 小肠结肠炎耶尔森氏菌检验 一次性试管、液体培养基 乳酸菌检验 菌落总数测定、无菌检验 显色培养基 植物组培

产品中心

当前位置:首页>产品中心

Human TIMP-2 Quantikine ELISA Kit (1 KT)

货号: DTM200 基本售价: 6791.4 元 规格: 1 Kit

产品信息

概述
货号DTM200
描述The Quantikine Human TIMP-2 Immunoassay is a 4.5 hour solid phase ELISA designed to measure TIMP-2 levels in cell culture supernates, serum, plasma, and saliva. It contains CHO cell-expressed recombinant human TIMP-2, and antibodies raised against the recombinant protein. Natural human TIMP-2 showed dose-response curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards, indicating that this kit can be used to determine relative levels of natural human TIMP-2.
别名CSC-21Ktissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2; TIMP-2; Tissue inhibitor of metalloproteinases 2;
全称
Tissue Inhibitors of Metalloproteinases 2
反应种属Human
目标/特异性Natural and recombinant human TIMP-2. This assay detects approximately 50% of recombinant human TIMP-2 when complexed with recombinant human active MMP-9 in a 1:1 molar ratio.
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
7077 (Human); 21858 (Mouse); 29543 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Role of serum VEGFA, TIMP2, MMP2 and MMP9 in monitoring response to adjuvant radiochemotherapy in patients with primary cervical cancer--results of a companion protocol of the randomized NOGGO-AGO phase III clinical trial.
Authors: Braicu E, Gasimli K, Richter R, Nassir M, Kummel S, Blohmer J, Yalcinkaya I, Chekerov R, Ignat I, Ionescu A, Mentze M, Fotopoulou C, Pop C, Lichtenegger W, Sehouli J
Anticancer Res, 2014;34(1):385-91.
Species: Human
Sample Type: Serum

Increased levels of leukocyte-derived MMP-9 in patients with stable angina pectoris.
Authors: Jonasson S, Lundberg A, Kalvegren H, Bergstrom I, Szymanowski A, Jonasson L
PLoS ONE, 2011;6(4):e19340.
Species: Human
Sample Type: Serum

Activation of matrix metalloproteinases following anti-Abeta immunotherapy; implications for microhemorrhage occurrence.
Authors: Wilcock DM, Morgan D, Gordon MN, Taylor TL, Ridnour LA, Wink DA, Colton CA
J Neuroinflammation, 2011;8(0):115.
Species: Mouse
Sample Type: Tissue Homogenates

Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood.
Authors: Sesso R, Franco MC
Am. J. Hypertens., 2010;23(1):6-11.
Species: Human
Sample Type: Plasma

Primary human acute myelogenous leukemia cells release matrix metalloproteases and their inhibitors: release profile and pharmacological modulation.
Authors: Reikvam H, Hatfield KJ, Oyan AM, Kalland KH, Kittang AO, Bruserud O
Eur. J. Haematol., 2010;84(3):239-51.
Species: Human
Sample Type: Cell Culture Supernates

Immunomodulation by chronobiologically-based glucocorticoids treatment for multiple sclerosis relapses.
Authors: Glass-Marmor L, Paperna T, Galboiz Y, Miller A
J. Neuroimmunol., 2009;210(1):124-7.
Species: Human
Sample Type: Serum

Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome.
Authors: OKane CM, McKeown SW, Perkins GD, Bassford CR, Gao F, Thickett DR, McAuley DF
Crit. Care Med., 2009;37(7):2242-9.
Species: Human
Sample Type: BALF

MMP expression and abnormal lung permeability are important determinants of outcome in IPF.
Authors: McKeown S, Richter AG, OKane C, OKane C, McAuley DF, Thickett DR
Eur. Respir. J., 2009;33(1):77-84.
Species: Human
Sample Type: BALF

Impact of acute exposure to tobacco smoke on gelatinases in the bronchoalveolar space.
Authors: Glader P, Eldh B, Bozinovski S, Andelid K, Sjostrand M, Malmhall C, Anderson GP, Riise GC, Qvarfordt I, Linden A
Eur. Respir. J., 2008;32(3):644-50.
Species: Human
Sample Type: BALF

Imbalance of tissue inhibitors of metalloproteinases (TIMP) - 1 and - 4 serum levels, in patients with inflammatory bowel disease.
Authors: Kapsoritakis AN, Kapsoritaki AI, Davidi IP, Lotis VD, Manolakis AC, Mylonis PI, Theodoridou AT, Germenis AE, Potamianos SP
BMC Gastroenterol, 2008;8(1):55.
Species: Human
Sample Type: Serum

Matrix metalloproteinase-2 dysregulation in type 1 diabetes.
Authors: Thrailkill KM, Bunn RC, Moreau CS, Cockrell GE, Simpson PM, Coleman HN, Frindik JP, Kemp SF, Fowlkes JL
Diabetes Care, 2007;30(9):2321-6.
Species: Human
Sample Type: Plasma

Is metalloproteinase-7 specific for idiopathic pulmonary fibrosis?
Authors: Huh JW, Kim DS, Oh YM, Shim TS, Lim CM, Lee SD, Koh Y, Kim WS, Kim WD, Kim KR
Chest, 2007;133(5):1101-6.
Species: Human
Sample Type: BALF

Actinobacillus actinomycetemcomitans lipopolysaccharide regulates matrix metalloproteinase, tissue inhibitors of matrix metalloproteinase, and plasminogen activator production by human gingival fibroblasts: a potential role in connective tissue destruction.
Authors: Bodet C, Andrian E, Tanabe S, Grenier D
J. Cell. Physiol., 2007;212(1):189-94.
Species: Human
Sample Type: Cell Culture Supernates

Plasma MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 during human orthotopic liver transplantation. The effect of aprotinin and the relation to ischemia/reperfusion injury.
Authors: Kuyvenhoven JP, Molenaar IQ, Verspaget HW, Veldman MG, Palareti G, Legnani C, Moolenburgh SE, Terpstra OT, Lamers CB, van Hoek B, Porte RJ
Thromb. Haemost., 2004;91(3):506-13.
Species: Human
Sample Type: Plasma

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in sera and tissue of patients with Dupuytrens disease.
Authors: Ulrich D, Hrynyschyn K, Pallua N
Plast. Reconstr. Surg., 2003;112(5):1279-86.
Species: Human
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
背景TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
运输条件Blue Ice
存放说明4℃
参考文献
  • Cancer Biomarkers
  • Extracellular Matrix Remodeling and Cell Migration During EMT
  • ICC / IHC Images: TIMP-2
  • Inflammatory Mediators
  • Metalloproteases and Regulators
  • MMPs, TIMPs and Related Molecules
  • OSM Induction of Chondrocyte MMP and TIMP-3 Gene Expression