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Human CCL20/MIP-3 alpha Quantikine ELISA Kit (1 KT)

货号: DM3A00 基本售价: 6791.4 元 规格: 1 Kit

产品信息

概述
货号DM3A00
描述The Quantikine Human MIP-3 alpha Immunoassay is a 4.5 hour solid phase ELISA designed to measure MIP-3 alpha levels in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human MIP-3 alpha and antibodies raised against the recombinant protein. Results obtained for naturally occurring human MIP-3 alpha showed linear curves that were parallel to the standard curves obtained using the kit standards. These results indicate that this kit can be used to determine relative mass values for natural human MIP-3 alpha.
别名beta chemokine exodus-1; Beta-chemokine exodus-1; CC chemokine LARC; C-C motif chemokine 20; chemokine (C-C motif) ligand 20; CKb4; exodus-1; LARC; LARCLiver and activation-regulated chemokine; MIP-3 alpha; MIP-3a; MIP-3-alpha; MIP3AMacrophage inflammatory protein 3 alpha; SCYA20Small-inducible cytokine A20; small inducible cytokine subfamily A (Cys-Cys), member 20; ST38;
反应种属Human
目标/特异性Natural and recombinant human MIP-3 alpha
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
6364 (Human); 20297 (Mouse); 29538 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
Authors: Li W, Liu H
Scand J Immunol, 2015;83(1):33-7.
Species: Human
Sample Type: Tissue Homogenates

Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.
Authors: Zhan Z, Xie X, Cao H, Zhou X, Zhang X, Fan H, Liu Z
Autophagy, 2014;10(2):257-68.
Species: Human
Sample Type: Cell Culture Supernates

Selective impact of HIV disease progression on the innate immune system in the human female reproductive tract.
Authors: Lahey T, Ghosh M, Fahey JV, Shen Z, Mukura LR, Song Y, Cu-Uvin S, Mayer KH, Wright PF, Kappes JC, Ochsenbauer C, Wira CR
PLoS ONE, 2012;7(6):e38100.
Species: Human
Sample Type: cervicovaginal lavage

A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel.
Authors: Keller MJ, Madan RP, Torres NM
PLoS ONE, 2011;6(1):e16475.
Species: Human
Sample Type: cervicovaginal lavage

IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma.
Authors: Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
Clin. Cancer Res., 2011;17(24):7529-38.
Species: Human
Sample Type: Serum

Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells.
Authors: Ramirez JM, Brembilla NC, Sorg O, Chicheportiche R, Matthes T, Dayer JM, Saurat JH, Roosnek E, Chizzolini C
Eur. J. Immunol., 2010;40(9):2450-9.
Species: Human
Sample Type: Cell Culture Supernates

Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor.
Authors: Charles J, Di Domizio J, Salameire D, Bendriss-Vermare N, Aspord C, Muhammad R, Lefebvre C, Plumas J, Leccia MT, Chaperot L
J. Invest. Dermatol., 2010;130(6):1646-56.
Species: Human
Sample Type: Cell Culture Supernates

Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells.
Authors: Xu G, Zhang L, Wang DY, Xu R, Liu Z, Han DM, Wang XD, Zuo KJ, Li HB
Allergy, 2010;65(5):581-9.
Species: Human
Sample Type: Cell Culture Supernates

Genome-wide comparison between IL-17A- and IL-17F-induced effects in human rheumatoid arthritis synoviocytes.
Authors: Zrioual S, Ecochard R, Tournadre A, Lenief V, Cazalis MA, Miossec P
J. Immunol., 2009;182(0):3112-20.
Species: Human
Sample Type: Cell Culture Supernates

HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells.
Authors: Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, Stingl G, Eppel W, Elbe-Burger A
J. Exp. Med., 2009;206(1):169-81.
Species: Human
Sample Type: Cell Culture Supernates

Th17 Cytokines Stimulate CCL20 Expression in Keratinocytes In Vitro and In Vivo: Implications for Psoriasis Pathogenesis.
Authors: Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, Skorcheva I, Purdy D, Fitch E, Iordanov M, Blauvelt A
J. Invest. Dermatol., 2009;129(0):2175.
Species: Human
Sample Type: Cell Culture Supernates

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
J. Exp. Med., 2009;206(3):535-48.
Species: Human
Sample Type: Cell Culture Supernates

Intratumoral induction of CD103 triggers tumor-specific CTL function and CCR5-dependent T-cell retention.
Authors: Franciszkiewicz K, Le Floch A, Jalil A, Vigant F, Robert T, Vergnon I, Mackiewicz A, Benihoud K, Validire P, Chouaib S, Combadiere C, Mami-Chouaib F
Cancer Res., 2009;69(15):6249-55.
Species: Human
Sample Type: Cell Culture Supernates

The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis.
Authors: Narbutt J, Lesiak A, Sysa-Jedrzeiowska A, Zakrzewski M, Bogaczewicz J, Stelmach I, Kuna P
Mediators Inflamm., 2009;2009(0):269541.
Species: Human
Sample Type: Serum

Urinary fractalkine is a marker of acute rejection.
Authors: Peng W, Chen J, Jiang Y, Wu J, Shou Z, He Q, Wang Y, Chen Y, Wang H
Kidney Int., 2008;74(11):1454-60.
Species: Human
Sample Type: Urine

Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation.
Authors: Maru SV, Holloway KA, Flynn G, Lancashire CL, Loughlin AJ, Male DK, Romero IA
J. Neuroimmunol., 2008;199(1):35-45.
Species: Human
Sample Type: Cell Culture Supernates

Macrophage inflammatory protein-3alpha is a novel serum marker for nasopharyngeal carcinoma detection and prediction of treatment outcomes.
Authors: Chang KP, Hao SP, Chang JH, Wu CC, Tsang NM, Lee YS, Hsu CL, Ueng SH, Liu SC, Liu YL, Wei PC, Liang Y, Chang YS, Yu JS
Clin. Cancer Res., 2008;14(21):6979-87.
Species: Human
Sample Type: Serum

Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells.
Authors: Baumforth KR, Birgersdotter A, Reynolds GM, Wei W, Kapatai G, Flavell JR, Kalk E, Piper K, Lee S, Machado L, Hadley K, Sundblad A, Sjoberg J, Bjorkholm M, Porwit AA, Yap LF, Teo S, Grundy RG, Young LS, Ernberg I, Woodman CB, Murray PG
Am. J. Pathol., 2008;173(1):195-204.
Species: Human
Sample Type: Cell Culture Supernates

Evidence for a pathogenetic role of interleukin-18 in cutaneous lupus erythematosus.
Authors: Wang D, Drenker M, Eiz-Vesper B, Werfel T, Wittmann M
Arthritis Rheum., 2008;58(10):3205-15.
Species: Human
Sample Type: Cell Culture Supernates

Specificity of immunomodulator secretion in urinary samples in response to infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli.
Authors: Real JM, Munro P, Buisson-Touati C, Lemichez E, Boquet P, Landraud L
Cytokine, 2007;37(1):22-5.
Species: Human
Sample Type: Urine

Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease.
Authors: Demedts IK, Bracke KR, Van Pottelberge G, Testelmans D, Verleden GM, Vermassen FE, Joos GF, Brusselle GG
Am. J. Respir. Crit. Care Med., 2007;175(10):998-1005.
Species: Human
Sample Type: Sputum

Airway dendritic cell phenotypes in inflammatory diseases of the human lung.
Authors: Lommatzsch M, Bratke K, Bier A, Julius P, Kuepper M, Luttmann W, Virchow JC
Eur. Respir. J., 2007;30(5):878-86.
Species: Human
Sample Type: BALF

Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene.
Authors: Bosco MC, Puppo M, Santangelo C, Anfosso L, Pfeffer U, Fardin P, Battaglia F, Varesio L
J. Immunol., 2006;177(3):1941-55.
Species: Human
Sample Type: Cell Culture Supernates

Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells.
Authors: Fichorova RN, Trifonova RT, Gilbert RO, Costello CE, Hayes GR, Lucas JJ, Singh BN
Infect. Immun., 2006;74(10):5773-9.
Species: Human
Sample Type: Cell Culture Supernates

Expression of CCL20 and granulocyte-macrophage colony-stimulating factor, but not Flt3-L, from modified vaccinia virus ankara enhances antiviral cellular and humoral immune responses.
Authors: Chavan R, Marfatia KA, An IC, Garber DA, Feinberg MB
J. Virol., 2006;80(15):7676-87.
Species: Human
Sample Type: Cell Culture Supernates

An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.
Authors: Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG
J. Exp. Med., 2006;203(12):2763-77.
Species: Human
Sample Type: Cell Culture Supernates

Glycerol monolaurate inhibits the effects of Gram-positive select agents on eukaryotic cells.
Authors: Peterson ML, Schlievert PM
Biochemistry, 2006;45(7):2387-97.
Species: Human
Sample Type: Cell Culture Supernates

Role for cysteinyl leukotrienes in allergen-induced change in circulating dendritic cell number in asthma.
Authors: Parameswaran K, Liang H, Fanat A, Watson R, Snider DP, O'Byrne PM
J. Allergy Clin. Immunol., 2004;114(1):73-9.
Species: Human
Sample Type: Sputum

Plasticity of airway epithelial cell transcriptome in response to flagellin.
Authors: Clark J, Kim K, Basom R, Gharib S
PLoS ONE, 0;10(2):e0115486.
Species: Human
Sample Type: Cell Culture Supernates

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景Macrophage inflammatory protein 3 alpha (MIP-3 alpha), also known as LARC (liver and activation-regulated chemokine) and as exodus-1, is one of many novel CC chemokines identified through bioinformatics. MIP-3 alpha is distantly related to other CC chemokines (20 - 28% amino acid sequence identity). Rat MIP-3 alpha shares approximately 70% and 61% amino acid sequence identity with mouse and human MIP-3 alpha, respectively.
运输条件Blue Ice
存放说明4℃
参考文献
  • CC Chemokines and Receptors
  • Chemokines and Receptors
  • Chemokines and Receptors in Angiogenesis
  • ICC / IHC Images: CCL20/MIP-3 alpha
  • Macrophage Activation Markers
  • Neural Activation Triggers CCL20 Expression & Promotes T Cell Entry into the Spinal Cord in a Mouse Model of Multiple Sclerosis
  • Regulatory T Cells (Tregs)
  • Th17 Cells