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Human CD14 Quantikine ELISA Kit (1 KT)

货号: DC140 基本售价: 6791.4 元 规格: 1 Kit

产品信息

概述
货号DC140
描述The Quantikine Human soluble CD14 Immunoassay is a 4.5 hour solid phase ELISA designed to measure human soluble CD14 in cell culture supernates, serum, and plasma. It contains recombinant human CD14 expressed from CHO cells and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained measuring natural human sCD14 showed dose-response curves that were parallel to the standard curves obtained using the kit standards. These results indicate that this kit can be used to determine relative mass values for natural human sCD14.
别名CD14 antigen; CD14 molecule; CD14; monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein;
反应种属Human
目标/特异性Natural and recombinant human sCD14
性能
供应商R&D Systems
检测类型Solid Phase Sandwich ELISA
Entrez Gene IDs
929 (Human); 12475 (Mouse); 60350 (Rat); 100037938 (Porcine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection
Authors: D Paquin-Pro, C Ching, I Vujkovic-C, D Fadrosh, L Loh, Y Huang, M Somsouk, SV Lynch, PW Hunt, DF Nixon, D SenGupta
Mucosal Immunol, 2016;0(0):.
Species: Human
Sample Type: Plasma

Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques.
Authors: Pandrea I, Xu C, Stock J, Frank D, Ma D, Policicchio B, He T, Kristoff J, Cornell E, Haret-Richter G, Trichel A, Ribeiro R, Tracy R, Wilson C, Landay A, Apetrei C
PLoS Pathog, 2016;12(1):e1005384.
Species: Human
Sample Type: Plasma

Widespread activation of immunity and pro-inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange
Authors: K Crothers, I Petrache, C Wongtrakoo, PJ Lee, LM Schnapp, SA Gharib
Physiol Rep, 2016;4(8):.
Species: Human
Sample Type: Serum

Immunity in young adult survivors of childhood leukemia is more similar to elderly rather than age-matched controls: Role of cytomegalovirus (CMV)
Eur J Immunol, 2016;0(0):.
Species: Human
Sample Type: Plasma

HCV Specific IL-21 Producing T Cells but Not IL-17A Producing T Cells Are Associated with HCV Viral Control in HIV/HCV Coinfection
PLoS ONE, 2016;11(4):e0154433.
Species: Human
Sample Type: Plasma

P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART
Authors: I Menkova-Ga, H Hocini, E Foucat, P Tisserand, L Bourdery, C Delaugerre, C Benne, Y Lévy, JD Lelièvre
PLoS Pathog, 2016;12(4):e1005571.
Species: Human
Sample Type: Plasma

Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression.
Authors: Claiborne, Daniel T, Prince, Jessica, Scully, Eileen, Macharia, Gladys, Micci, Luca, Lawson, Benton, Kopycinski, Jakub, Deymier, Martin J, Vanderford, Thomas H, Nganou-Makamdop, Krystell, Ende, Zachary, Brooks, Kelsie, Tang, Jianming, Yu, Tianwei, Lakhi, Shabir, Kilembe, William, Silvestri, Guido, Douek, Daniel, Goepfert, Paul A, Price, Matthew, Allen, Susan A, Paiardini, Mirko, Altfeld, Marcus, Gilmour, Jill, Hunter, Eric
Proc Natl Acad Sci U S A, 2015;112(12):E1480-9.
Species: Human
Sample Type: Plasma

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption.
Authors: Rothenberger, Meghan K, Keele, Brandon, Wietgrefe, Stephen, Fletcher, Courtney, Beilman, Gregory, Chipman, Jeffrey, Khoruts, Alexande, Estes, Jacob D, Anderson, Jodi, Callisto, Samuel P, Schmidt, Thomas E, Thorkelson, Ann, Reilly, Cavan, Perkey, Katherin, Reimann, Thomas G, Utay, Netanya, Nganou Makamdop, Krystell, Stevenson, Mario, Douek, Daniel C, Haase, Ashley T, Schacker, Timothy
Proc Natl Acad Sci U S A, 2015;112(10):E1126-34.
Species: Human
Sample Type: Plasma

The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial.
Authors: Somsouk, Ma, Dunham, Richard, Cohen, Michelle, Albright, Rebecca, Abdel-Mohsen, Mohamed, Liegler, Teri, Lifson, Jeffrey, Piatak, Michael, Gorelick, Robert, Huang, Yong, Wu, Yuaner, Hsue, Priscill, Martin, Jeffrey, Deeks, Steven G, McCune, Joseph M, Hunt, Peter W
PLoS ONE, 2015;9(12):e116306.
Species: Human
Sample Type: Plasma

Loss of intraepidermal nerve fiber density during SIV peripheral neuropathy is mediated by monocyte activation and elevated monocyte chemotactic proteins.
Authors: Lakritz J, Robinson J, Polydefkis M, Miller A, Burdo T
J Neuroinflammation, 2015;12(0):237.
Species: Primate
Sample Type: Plasma

Late Antiretroviral Therapy (ART) Initiation Is Associated with Long-Term Persistence of Systemic Inflammation and Metabolic Abnormalities.
Authors: Ghislain M, Bastard J, Meyer L, Capeau J, Fellahi S, Gerard L, May T, Simon A, Vigouroux C, Goujard C
PLoS ONE, 2015;10(12):e0144317.
Species: Human
Sample Type: Serum

Shift in monocyte apoptosis with increasing viral load and change in apoptosis-related ISG/Bcl2 family gene expression in chronically HIV-1-infected subjects.
Authors: Patro S, Pal S, Bi Y, Lynn K, Mounzer K, Kostman J, Davuluri R, Montaner L
J Virol, 2015;89(1):799-810.
Species: Human
Sample Type: Plasma

Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring?
Authors: Castley, Alison, Berry, Cassandr, French, Martyn, Fernandez, Sonia, Krueger, Romano, Nolan, David
PLoS ONE, 2014;9(12):e115226.
Species: Human
Sample Type: Plasma

Plasma sCD14 as a biomarker to predict pulmonary exacerbations in cystic fibrosis.
Authors: Quon B, Ngan D, Wilcox P, Man S, Sin D
PLoS ONE, 2014;9(2):e89341.
Species: Human
Sample Type: Plasma

Decreased IL-7 responsiveness is related to oxidative stress in HIV disease.
Authors: Kalinowska M, Bazdar D, Lederman M, Funderburg N, Sieg S
PLoS ONE, 2013;8(3):e58764.
Species: Human
Sample Type: Serum

Transcriptional effects of 1,25 dihydroxyvitamin D(3) physiological and supra-physiological concentrations in breast cancer organotypic culture.
Authors: Milani C, Katayama M, de Lyra E, Welsh J, Campos L, Brentani M, Maciel M, Roela R, del Valle P, Goes J, Nonogaki S, Tamura R, Folgueira M
BMC Cancer, 2013;13(0):119.
Species: Human
Sample Type: cell culture supernate

Dynamics of immune reconstitution and activation markers in HIV+ treatment-naive patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine.
Authors: Funderburg N, Andrade A, Chan E, Rosenkranz S, Lu D, Clagett B, Pilch-Cooper H, Rodriguez B, Feinberg J, Daar E, Mellors J, Kuritzkes D, Jacobson J, Lederman M
PLoS ONE, 2013;8(12):e83514.
Species: Human
Sample Type: Plasma

SIVagm infection in wild African green monkeys from South Africa: epidemiology, natural history, and evolutionary considerations.
Authors: Ma, Dongzhu, Jasinska, Anna, Kristoff, Jan, Grobler, J Paul, Turner, Trudy, Jung, Yoon, Schmitt, Christop, Raehtz, Kevin, Feyertag, Felix, Martinez Sosa, Natalie, Wijewardana, Viskam, Burke, Donald S, Robertson, David L, Tracy, Russell, Pandrea, Ivona, Freimer, Nelson, Apetrei, Cristian
PLoS Pathog, 2013;9(1):e1003011.
Species: Primate - Chlorocebus pygerythrus (African Green Monkey)
Sample Type: Plasma

Relationship between microbial translocation and endothelial function in HIV infected patients.
Authors: Blodget E, Shen C, Aldrovandi G, Rollie A, Gupta S, Stein J, Dube M
PLoS ONE, 2012;7(8):e42624.
Species: Human
Sample Type: Plasma

Altered monocyte activation markers in Tourette's syndrome: a case-control study.
Authors: Matz J, Krause DL, Dehning S, Riedel M, Gruber R, Schwarz MJ, Muller N
BMC Psychiatry, 2012;12(0):29.
Species: Human
Sample Type: Serum

Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.
Authors: Broadhurst, Mara Jan, Ardeshir, Amir, Kanwar, Bittoo, Mirpuri, Julie, Gundra, Uma Mahe, Leung, Jacqueli, Wiens, Kirsten, Vujkovic-Cvijin, Ivan, Kim, Charlie, Yarovinsky, Felix, Lerche, Nicholas, McCune, Joseph M
Oncogene, 2012;8(11):e1003000.
Species: Human
Sample Type: Plasma

CD4 T follicular helper cell dynamics during SIV infection.
J. Clin. Invest., 2012;122(9):3281-94.
Species: Primate - Macaca mulatta (Rhesus monkey)
Sample Type: Plasma

Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome.
Authors: Funderburg, Nicholas, Zidar, David A, Shive, Carey, Lioi, Anthony, Mudd, Joseph, Musselwhite, Laura W, Simon, Daniel I, Costa, Marco A, Rodriguez, Benigno, Sieg, Scott F, Lederman, Michael
Blood, 2012;120(23):4599-608.
Species: Human
Sample Type: Plasma

The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis.
Authors: Ngan D, Wilcox P, Aldaabil M, Li Y, Leipsic J, Sin D, Man S
BMC Pulm Med, 2012;12(0):3.
Species: Human
Sample Type: Plasma

Epithelial adhesion molecules can inhibit HIV-1-specific CD8+ T-cell functions.
Authors: Streeck H, Kwon DS, Pyo A, Flanders M, Chevalier MF, Law K, Julg B, Trocha K, Jolin JS, Anahtar MN, Lian J, Toth I, Brumme Z, Chang JJ, Caron T, Rodig SJ, Milner DA, Piechoka-Trocha A, Kaufmann DE, Walker BD, Altfeld M
Blood, 2011;117(19):5112-22.
Species: Human
Sample Type: Plasma

Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infection.
Authors: Ford ES, Greenwald JH, Richterman AG
AIDS, 2010;24(10):1509-17.
Species: Human
Sample Type: Plasma

Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation.
Authors: Funderburg NT, Mayne E, Sieg SF
Blood, 2010;115(2):161-7.
Species: Human
Sample Type: Plasma

Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring.
Authors: Holmlund U, Amoudruz P, Johansson MA, Haileselassie Y, Ongoiba A, Kayentao K, Traore B, Doumbo S, Schollin J, Doumbo O, Montgomery SM, Sverremark-Ekstrom E
Clin. Exp. Immunol., 2010;162(3):500-9.
Species: Human
Sample Type: Milk

Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population.
Authors: Miller MA, McTernan PG, Harte AL, Silva NF, Strazzullo P, Alberti KG, Kumar S, Cappuccio FP
Atherosclerosis, 2009;203(2):494-502.
Species: Human
Sample Type: Plasma

Cutting edge: Experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletion.
Authors: Pandrea I, Gaufin T, Brenchley JM, Gautam R, Monjure C, Gautam A, Coleman C, Lackner AA, Ribeiro RM, Douek DC, Apetrei C
J. Immunol., 2008;181(10):6687-91.
Species: Primate – Chlorocebus pygerythrus (Vervet/African Green Monkey)
Sample Type: Plasma

Breast milk fatty acids may link innate and adaptive immune regulation: analysis of soluble CD14, prostaglandin E2, and fatty acids.
Authors: Laitinen K, Hoppu U, Hamalainen M, Linderborg K, Moilanen E, Isolauri E
Pediatr. Res., 2006;59(5):723-7.
Species: Human
Sample Type: Serum

CD14 is an acute-phase protein.
Authors: Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C
J. Immunol., 2004;172(7):4470-9.
Species: Human
Sample Type: Serum

TGF-beta in human milk is associated with wheeze in infancy.
Authors: Oddy WH, Halonen M, Martinez FD, Lohman IC, Stern DA, Kurzius-Spencer M, Guerra S, Wright AL
J. Allergy Clin. Immunol., 2003;112(4):723-8.
Species: Human
Sample Type: Milk

Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age.
Authors: Guerra S, Lohman IC, Halonen M, Martinez FD, Wright AL
Am. J. Respir. Crit. Care Med., 2003;169(1):70-6.
Species: Human
Sample Type: Serum

生物活性< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
背景CD14 is an acute phase glycoprotein that binds lipopolysaccharide endotoxins (LPS) from Gram-negative bacteria. It is primarily expressed on monocytes, macrophages, and neutrophils, and soluble forms can be secreted or shed from the cell surface. CD14 accepts LPS from its initial binding by LBP, and it can further transfer LPS to the TLR4/MD2 complex. LPS acctivation of TLR4 triggers inflammatory activation. CD14 also contributes to the response to TLR3 ligands, phosphoinositides, as well as the surfactant proteins SP-A and SP-D.
运输条件Blue Ice
存放说明4℃
参考文献
  • Common Macrophage Markers
  • Conventional/Classical Dendritic Cells
  • Human CD Marker Products
  • ICC / IHC Images: CD14
  • Inflammatory Mediators
  • Inflammatory/Monocyte-derived Dendritic Cells
  • Langerhans and Dermal Dendritic Cells
  • Leukocyte Receptors/Markers in Allergy and Asthma
  • Monocyte Markers
  • Myeloid Lineage Markers
  • Myeloid-derived Suppressor Cells (MDSC)
  • New Tools: Sepsis Research
  • Plasmacytoid Dendritic Cells
  • Toll-Like Receptors