Rat CXCL2/CINC-3 Quantikine ELISA Kit (1 KT)【科瑞奥博】

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Rat CXCL2/CINC-3 Quantikine ELISA Kit (1 KT)

货号： RCN300 基本售价： 6791.4 元规格： 1 Kit

产品信息

概述
货号	RCN300
描述	The Quantikine Rat CINC-3 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure rat CINC-3 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant rat CINC-3 and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural rat CINC-3 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring rat CINC-3.
别名	chemokine (C-X-C motif) ligand 2; CINC-2a; CINC-3; C-X-C Motif Chemokine 2; GRO beta; GRO2 oncogene; GRO2; GROB; Gro-beta; Growth-regulated protein beta; Macrophage inflammatory protein 2-alpha; melanoma growth stimulatory activity beta; MGSA beta; MGSA-b; MGSA-beta; MIP2; MIP-2; MIP2A; MIP-2a; MIP2-alpha; SCYB2;
反应种属	Rat
目标/特异性	Natural and recombinant rat CINC-3

性能
供应商	R&D Systems
检测类型	Solid Phase Sandwich ELISA
Entrez Gene IDs	2920 (Human); 20310 (Mouse); 114105 (Rat)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. NF-kappaB and STAT1 control CXCL1 and CXCL2 gene transcription. Authors: Burke S, Lu D, Sparer T, Masi T, Goff M, Karlstad M, Collier J Am J Physiol Endocrinol Metab, 2014;306(2):E131-49. Species: Rat Sample Type: Cell Culture Supernates Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury model. Authors: Ding N, Wang F, Xiao H, Xu L, She S PLoS ONE, 2013;8(9):e74633. Species: Rat Sample Type: BALF A short course of infusion of a hydrogen sulfide-donor attenuates endotoxemia induced organ injury via stimulation of anti-inflammatory pathways, with no additional protection from prolonged infusion. Cytokine, 2013;61(2):614-21. Species: Rat Sample Type: BALF P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways. Authors: Shiratori M, Tozaki-Saitoh H, Yoshitake M J. Neurochem., 2010;114(3):810-9. Species: Rat Sample Type: Cell Culture Supernates Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses. Authors: Yang S, Hu S, Chen J, Choudhry MA, Rue LW, Bland KI, Chaudry IH J. Leukoc. Biol., 2009;85(6):1015-26. Species: Rat Sample Type: Serum Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats. Authors: Choi G, Hofstra JJ, Roelofs JJ, Rijneveld AW, Bresser P, van der Zee JS, Florquin S, van der Poll T, Levi M, Schultz MJ Crit. Care Med., 2008;36(1):204-10. Species: Rat Sample Type: BALF Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage. Authors: Yang S, Hu S, Choudhry MA, Rue LW, Bland KI, Chaudry IH J. Mol. Cell. Cardiol., 2007;42(3):620-30. Species: Rat Sample Type: Tissue Homogenates Natural anticoagulants limit lipopolysaccharide-induced pulmonary coagulation but not inflammation. Authors: Choi G, Vlaar AP, Schouten M, Vant Veer C, van der Poll T, Levi M, Schultz MJ Eur. Respir. J., 2007;30(3):423-8. Species: Rat Sample Type: Tissue Homogenates ACE mediates ventilator-induced lung injury in rats via angiotensin II but not bradykinin. Authors: Wosten-van Asperen RM, Lutter R, Haitsma JJ, Merkus MP, van Woensel JB, van der Loos CM, Florquin S, Lachmann B, Bos AP Eur. Respir. J., 2007;31(2):363-71. Species: Rat Sample Type: BALF Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway. Authors: Yu HP, Hsieh YC, Suzuki T, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH J. Leukoc. Biol., 2007;82(3):774-80. Species: Rat Sample Type: Tissue Homogenates Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage. Authors: Yang S, Hu S, Hsieh YC, Choudhry MA, Rue LW, Bland KI, Chaudry IH J. Mol. Cell. Cardiol., 2006;40(4):570-9. Species: Rat Sample Type: Tissue Homogenates Maintenance of lung myeloperoxidase activity in proestrus females after trauma-hemorrhage: upregulation of heme oxygenase-1. Authors: Yu HP, Yang S, Hsieh YC, Choudhry MA, Bland KI, Chaudry IH Am. J. Physiol. Lung Cell Mol. Physiol., 2006;291(3):L400-6. Species: Rat Sample Type: Tissue Homogenates
生物活性	< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
背景	CXCL2/GRO beta, also called MIP-2 in mouse and CINC-3 in rat, is a member of the CXC chemokine family. Human CXCL2/GRO beta is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 70% and 71% aa sequence identity with the human protein, respectively. N-terminal aa 1-4 of CXCL2/GRO beta can be post-translationally cleaved which confers enhanced hematopoietic bioactivity. CXCL2/GRO beta is produced by a variety of cell types including monocytes and macrophages at sites of inflammation and is chemotactic for granulocytes, including neutrophils.
运输条件	Blue Ice
存放说明	4℃
参考文献	Chemokines and Receptors in Angiogenesis CXC Chemokines and Receptors ICC / IHC Images: CXCL2/GRO beta/MIP-2/CINC-3 Inflammatory Mediators Macrophage Activation Markers Neuroinflammation