Human IL-6 ELISA Kit (Colorimetric)
货号：
NBP2-31051 基本售价：
3648.5 元 规格：
1 Kit
产品信息
概述| 货号 | NBP2-31051 |
| 反应种属 | HuSpecies Glossary |
| 应用 | ELISA |
性能| 供应商 | Novus |
| 免疫原 | Human IL-6 Activ ELISA |
| 背景 | IL-6 is a cytokine that functions in inflammation, and maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response. This classical responsiveness to IL-6 is governed by a receptor complex consisting of two membrane-bound subunits, an 80-kDa cognate Alpha-chain (IL-6R-Alpha), and a ubiquitously expressed 130-kDa Beta-chain receptor (gp130) which acts as the universal signal transducing element for all IL-6 family cytokines. Alternatively, IL-6 regulation of leukocyte trafficking relies upon signaling via its soluble IL-6R Alpha (termed IL-6 trans-signaling) (Fielding CA et al, 2008). IL-6 trans-signals via STAT3 which acts as a critical modulator of LPS-driven proinflammatory responses through cross-talk regulation of the TLR4/Mal signaling pathway, and potentially implicate cross-talk between JAK/STAT and TLR pathways as a broader mechanism that regulates the severity of the host inflammatory response (Greenhill CJ et al, 2011). After this initial wave of proinflammatory cytokine production, antiinflammatory cytokines such as TGF-Beta and IL-10 are produced to dampen the TLR4-driven production of proinflammatory cytokines. Thus functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including susceptibility to diabetes mellitus and systemic juvenile rheumatoid arthritis (Takeda K et al, 2003). |
| 存放说明 | Storage is content dependent. |
