| 货号 | 2855-KS-010 |
| 别名 | ERK activator kinase 2; MAP2K2; MAPKK 2; MEK 2; MEK2EC 2.7.12.2; mitogen-activated protein kinase kinase 2; MKK2; MKK2FLJ26075; p45; PRKMK2MAPKK2 | 全称 | Mitogen-activated Protein Kinase Kinase 2 |
| 反应种属 | Human |
| 来源 | Spodoptera frugiperda,Sf 9 (baculovirus)-derived Accession # NM_030662 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 5605 (Human); 26396 (Mouse) |
| 生物活性 | The activity of MEK2 is typically 190-258 nmol/min/mg using an ERK2 substrate and a myelin basic protein (MBP) substrate (see Activity Assay Protocol). |
| 背景 | MEK2 is the member of MAPK kinase (MAPKK) family of signaling protein kinases. MEK2 is a dual-specificity kinase that activates the extracellular signal-regulated kinase (ERK) and mitogen-activated protein (MAP) kinase upon agonist binding to receptors. MEK2 plays a key role in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK) signaling pathways (1). Approximately 30% of all human cancers have a constitutively activated MAPK pathway, and constitutive activation of MEK2 results in cellular transformation. The ERK/MAP kinase cascade regulates cell growth and differentiation (2). |
| Accession # | NM_030662 |
| 运输条件 | Dry Ice |
| N-terminal Sequence Analysis | Using an N terminal GST tag |
| SDS-PAGE | 71 kDa |
| 存放说明 | -80℃ |
| 纯度 | >70%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain at 5 μg per lane |
| 参考文献 |
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The approximate molecular weight is 71 kDa and the average purity is 90%. |
