Mouse IL-17 MAb (Clone 50104) (500 UG)【科瑞奥博】

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Mouse IL-17 MAb (Clone 50104) (500 UG)

货号： MAB421-500 基本售价： 10360.6 元规格： 500 ug

产品信息

概述
货号	MAB421-500
别名	CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A
全称	Interleukin 17
反应种属	Mouse
应用	Western Blot(1 µg/mL)
目标/特异性	Detects mouse IL-17 in direct ELISAs and Western blots. In direct ELISAs, approximately 40% reactivity with recombinant mouse (rm) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant human IL-17, recombinant canine IL-17, rmIL-17B, rmIL‑17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed.
使用方法	Western Blot: 1 µg/mL Neutralization: Measured by its ability to neutralize IL‑17-induced IL‑6 secretion in the NIH‑3T3 mouse embryonic fibroblast cell line. Yao, Z. et al. (1995) Immunity 3:811. The Neutralization Dose (ND₅₀) is typically 0.05-0.15 µg/mL in the presence of 10 ng/mL Recombinant Mouse IL‑17.
来源	Monoclonal Rat IgG_2A Clone # 50104
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3605 (Human); 16171 (Mouse); 301289 (Rat); 481837 (Canine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. IL-17A Is an Important Effector of the Immune Response of the Mammary Gland to Escherichia coli Infection. Authors: Porcherie A, Gilbert F, Germon P, Cunha P, Trotereau A, Rossignol C, Winter N, Berthon P, Rainard P J Immunol, 2016;196(2):803-12. Species: Mouse Sample Type: In Vivo Application: In vivo Interleukin-27 Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response Authors: Gustavo F S Quirino Infect Immun, 2016;0(0):. Species: Mouse Sample Type: In Vivo Application: Neut Seminal plasma induces inflammation in the uterus through the ?? T/IL-17 pathway Authors: ZH Song, ZY Li, DD Li, WN Fang, HY Liu, DD Yang, CY Meng, Y Yang, JP Peng Sci Rep, 2016;6(0):25118. Species: Mouse Sample Type: In Vivo Application: In vivo Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice. Authors: Qi H, Yang H, Xu G, Ren J, Hua W, Shi Y, Torsvik M, Florholmen J, Cui G Immunobiology, 2015;220(1):54-9. Species: Mouse Sample Type: In Vivo Application: Blocking Dendritic Cells Regulate Treg-Th17 Axis in Obstructive Phase of Bile Duct Injury in Murine Biliary Atresia. Authors: Liu Y, Li K, Yang L, Tang S, Wang X, Cao G, Li S, Lei H, Zhang X PLoS ONE, 2015;10(9):e0136214. Species: Mouse Sample Type: In Vivo Application: Neut Neonatal Streptococcus pneumoniae infection may aggravate adulthood allergic airways disease in association with IL-17A. Authors: Yang B, Liu R, Yang T, Jiang X, Zhang L, Wang L, Wang Q, Luo Z, Liu E, Fu Z PLoS ONE, 2015;10(3):e0123010. Species: Mouse Sample Type: In Vivo Application: Neut IL17 Mediates Pelvic Pain in Experimental Autoimmune Prostatitis (EAP). Authors: Murphy S, Schaeffer A, Done J, Wong L, Bell-Cohn A, Roman K, Cashy J, Ohlhausen M, Thumbikat P PLoS ONE, 2015;10(5):e0125623. Species: Mouse Sample Type: In Vivo Application: Neut Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency. Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N J Immunol, 2015;194(11):5407-16. Species: Mouse Sample Type: In Vivo Application: Neut Interleukin-17A and Neutrophils in a Murine Model of Bird-Related Hypersensitivity Pneumonitis. Authors: Ishizuka M, Miyazaki Y, Masuo M, Suhara K, Tateishi T, Yasui M, Inase N PLoS ONE, 2015;10(9):e0137978. Species: Mouse Sample Type: In Vivo Application: Neut IKKbeta in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites. Authors: Bonnegarde-Bernard A, Jee J, Fial M, Aeffner F, Cormet-Boyaka E, Davis I, Lin M, Tome D, Karin M, Sun Y, Boyaka P Mucosal Immunol, 2014;7(2):257-67. Species: Mouse Sample Type: In Vivo Application: Functional Assay IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-gamma-activated macrophage programming. Authors: Bi Y, Zhou J, Yang H, Wang X, Zhang X, Wang Q, Wu X, Han Y, Song Y, Tan Y, Du Z, Yang H, Zhou D, Cui Y, Zhou L, Yan Y, Zhang P, Guo Z, Wang X, Liu G, Yang R J Immunol, 2014;192(2):704-13. Species: Mouse Sample Type: In Vivo Application: Neut Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis. Authors: Singh T, Schon M, Wallbrecht K, Gruber-Wackernagel A, Wang X, Wolf P PLoS ONE, 2013;8(1):e51752. Species: Mouse Sample Type: In Vivo Application: Neut Transcription factors GATA-3 and RORgammat are important for determining the phenotype of allergic airway inflammation in a murine model of asthma. Authors: Ano S, Morishima Y, Ishii Y, Yoh K, Yageta Y, Ohtsuka S, Matsuyama M, Kawaguchi M, Takahashi S, Hizawa N J Immunol, 2013;190(3):1056-65. Species: Mouse Sample Type: In Vivo Application: Neut Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis. Authors: Hou L, Jie Z, Desai M, Liang Y, Soong L, Wang T, Sun J J Immunol, 2013;190(2):621-9. Species: Mouse Sample Type: In Vivo Application: In vivo Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice. Authors: Noto Llana M, Sarnacki SH, Vazquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC Infect. Immun., 2012;80(6):2231-9. Species: Mouse Sample Type: In Vivo Application: InVivo IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung. Authors: Khader SA, Guglani L, Rangel-Moreno J J. Immunol., 2011;187(10):5402-7. Species: Mouse Sample Type: In Vivo Application: In vivo Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L J. Exp. Med., 2011;208(3):491-503. Species: Mouse Sample Type: Whole Cells Application: Neut Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells. Authors: Park SY, Gupta D, Kim CH PLoS ONE, 2011;6(9):e24961. Species: Mouse Sample Type: In Vivo Application: In vivo Innate immune responses to systemic Acinetobacter baumannii infection in mice: neutrophils, but not interleukin-17, mediate host resistance. Authors: Breslow JM, Meissler JJ, Hartzell RR Infect. Immun., 2011;79(8):3317-27. Species: Mouse Sample Type: In Vivo Application: In vivo TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice. Authors: Kim HS, Go H, Akira S, Chung DH J. Immunol., 2011;187(8):4007-17. Species: Mouse Sample Type: In Vivo Application: In vivo IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. Authors: Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brule S, Van Snick J, Uyttenhove C, Ryffel B, Renauld JC, Lison D, Huaux F J. Immunol., 2010;184(11):6367-77. Species: Mouse Sample Type: In Vivo Application: In vivo A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice. Authors: Gao Q, Jiang Y, Ma T, Zhu F, Gao F, Zhang P, Guo C, Wang Q, Wang X, Ma C, Zhang Y, Chen W, Zhang L J. Immunol., 2010;185(10):5820-7. Species: Mouse Sample Type: In Vivo Application: In vivo Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease. Authors: Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM J. Immunol., 2010;184(8):4159-69. Species: Mouse Sample Type: In Vivo Application: In vivo Lack of TNFR p55 results in heightened expression of IFN-gamma and IL-17 during the development of reactive arthritis. Authors: Elicabe RJ, Cargnelutti E, Serer MI, Stege PW, Valdez SR, Toscano MA, Rabinovich GA, Di Genaro MS J. Immunol., 2010;185(7):4485-95. Species: Mouse Sample Type: In Vivo Application: In vivo Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy. Authors: Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W PLoS ONE, 2010;5(10):e13349. Species: Mouse Sample Type: In Vivo Application: In vivo Th17 immune responses contribute to the pathophysiology of aplastic anemia. Authors: de Latour RP, Visconte V, Takaku T Blood, 2010;116(20):4175-84. Species: Mouse Sample Type: In Vivo Application: In vivo Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis. Authors: Wondimu Z, Santodomingo-Garzon T, Le T, Swain MG Am. J. Pathol., 2010;177(5):2334-46. Species: Mouse Sample Type: In Vivo Application: In vivo IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury. Authors: Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, Strieter RM, Rosin DL, Okusa MD J. Clin. Invest., 2010;120(1):331-42. Species: Mouse Sample Type: In Vivo Application: In vivo Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung. Authors: Redford PS, Boonstra A, Read S, Pitt J, Graham C, Stavropoulos E, Bancroft GJ, OGarra A Eur. J. Immunol., 2010;40(8):2200-10. Species: Mouse Sample Type: In Vivo Application: In vivo Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. Authors: Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, Saraiva M, Pereira DR, Randall TD, Pedrosa J, Cooper AM, Castro AG J. Exp. Med., 2010;207(8):1609-16. Species: Mouse Sample Type: In Vivo Application: In vivo Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta. Authors: Han G, Wang R, Chen G Immunology, 2010;129(2):197-206. Species: Mouse Sample Type: In Vivo Application: In vivo IL-22 defines a novel immune pathway of antifungal resistance. Authors: De Luca A, Zelante T, DAngelo C Mucosal Immunol, 2010;3(4):361-73. Species: Mouse Sample Type: In Vivo Application: In vivo A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Authors: Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL Nat. Med., 2009;15(9):1016-22. Species: Mouse Sample Type: In Vivo Application: In vivo IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function. Authors: Bai H, Cheng J, Gao X, Joyee AG, Fan Y, Wang S, Jiao L, Yao Z, Yang X J. Immunol., 2009;183(9):5886-95. Species: Mouse Sample Type: In Vivo Application: In vivo Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. Authors: He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS J. Allergy Clin. Immunol., 2009;124(4):761-70.e1. Species: Mouse Sample Type: In Vivo Application: In vivo Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation. Authors: Park SJ, Lee KS, Kim SR, Min KH, Choe YH, Moon H, Chae HJ, Yoo WH, Lee YC J. Immunol., 2009;183(5):3259-67. Species: Mouse Sample Type: In Vivo Application: In vivo Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. Authors: Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, Dana R J. Immunol., 2009;182(3):1247-52. Species: Mouse Sample Type: In Vivo Application: In vivo Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells. Authors: Yuan X, Ansari MJ, DAddio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH Proc. Natl. Acad. Sci. U.S.A., 2009;106(26):10734-9. Species: Mouse Sample Type: In Vivo Application: In vivo Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis. Authors: Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T Biochem. Biophys. Res. Commun., 2009;382(2):252-8. Species: Mouse Sample Type: In Vivo Application: In vivo Encephalitogenicity of complete Freunds adjuvant relative to CpG is linked to induction of Th17 cells. Authors: Tigno-Aranjuez JT, Jaini R, Tuohy VK, Lehmann PV, Tary-Lehmann M J. Immunol., 2009;183(9):5654-61. Species: Mouse Sample Type: In Vivo Application: In vivo A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. Authors: Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G J. Immunol., 2009;183(2):1291-300. Species: Mouse Sample Type: In Vivo Application: In vivo Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice. Authors: Zhang Z, Zhong W, Spencer D, Chen H, Lu H, Kawaguchi T, Rosenbaum JT Cytokine, 2009;46(1):79-91. Species: Mouse Sample Type: In Vivo Application: In vivo Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Authors: Oyoshi MK, Elkhal A, Kumar L, Scott JE, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, Geha RS Proc. Natl. Acad. Sci. U.S.A., 2009;106(35):14954-9. Species: Mouse Sample Type: In Vivo Application: In vivo Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge. Authors: Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW J. Immunol., 2009;182(6):3469-81. Species: Mouse Sample Type: In Vivo Application: In vivo Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Authors: Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T Arthritis Rheum., 2008;58(3):754-63. Species: Mouse Sample Type: In Vivo Application: In vivo A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity. Authors: Lee KA, Kang MH, Lee YS, Kim YJ, Kim DH, Ko HJ, Kang CY Cell. Immunol., 2008;251(1):50-5. Species: Mouse Sample Type: In Vivo Application: In vivo Promotion of the local differentiation of murine Th17 cells by synovial macrophages during acute inflammatory arthritis. Authors: Egan PJ, van Nieuwenhuijze A, Campbell IK, Wicks IP Arthritis Rheum., 2008;58(12):3720-9. Species: Mouse Sample Type: In Vivo Application: In vivo CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice. Authors: Burrell BE, Csencsits K, Lu G, Grabauskiene S, Bishop DK J. Immunol., 2008;181(6):3906-14. Species: Mouse Sample Type: In Vivo Application: In vivo Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice. Authors: Koenders MI, Devesa I, Marijnissen RJ, Abdollahi-Roodsaz S, Boots AM, Walgreen B, di Padova FE, Nicklin MJ, Joosten LA, van den Berg WB Arthritis Rheum., 2008;58(11):3461-70. Species: Mouse Sample Type: In Vivo Application: In vivo Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection. Authors: Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, DAngelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L J. Immunol., 2008;180(6):4022-31. Species: Mouse Sample Type: In Vivo Application: In vivo Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Authors: DAngelo C, Segal BH Nature, 2008;451(7175):211-5. Species: Mouse Sample Type: In Vivo Application: In vivo Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease. Authors: Mauermann N, Burian J, von Garnier C, Dirnhofer S, Germano D, Schuett C, Tamm M, Bingisser R, Eriksson U, Hunziker L Am. J. Respir. Crit. Care Med., 2008;178(4):379-88. Species: Mouse Sample Type: In Vivo Application: In vivo IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17. Authors: Kohyama S, Ohno S, Isoda A, Moriya O, Belladonna ML, Hayashi H, Iwakura Y, Yoshimoto T, Akatsuka T, Matsui M J. Immunol., 2007;179(6):3917-25. Species: Mouse Sample Type: In Vivo Application: In vivo Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Authors: He R, Oyoshi MK, Jin H, Geha RS Proc. Natl. Acad. Sci. U.S.A., 2007;104(40):15817-22. Species: Mouse Sample Type: In Vivo Application: In vivo IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Authors: Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L Eur. J. Immunol., 2007;37(10):2695-706. Species: Mouse Sample Type: In Vivo Application: In vivo T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways. Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H J. Allergy Clin. Immunol., 2007;119(3):662-70. Species: Mouse Sample Type: Whole Cells Application: Neut Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response. Authors: Irmler IM, Gajda M, Brauer R J. Immunol., 2007;179(9):6228-36. Species: Mouse Sample Type: In Vivo Application: In vivo Functional relevance of the IL-23-IL-17 axis in lungs in vivo. Authors: Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhall C, Sjostrand M, Kolls JK, Anderson GP, Linden A Am. J. Respir. Cell Mol. Biol., 2007;36(4):442-51. Species: Mouse Sample Type: Application: In vivo Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. Authors: Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, Hipkiss EL, Getnet D, Goldberg MV, Maris CH, Housseau F, Yu H, Pardoll DM, Drake CG J. Immunol., 2007;179(7):4313-7. Species: Mouse Sample Type: In Vivo Application: In vivo Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production. Authors: Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y J. Immunol., 2007;178(7):4466-72. Species: Mouse Sample Type: In Vivo Application: In vivo Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation. Authors: Sergejeva S, Ivanov S, Lotvall J, Linden A Am. J. Respir. Cell Mol. Biol., 2005;33(3):248-53. Species: Mouse Sample Type: Whole Cells Application: Neut Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways. Authors: Miyamoto M, Prause O, Sjostrand M, Laan M, Lotvall J, Linden A J. Immunol., 2003;170(9):4665-72. Species: Mouse Sample Type: In Vivo Application: In vivo Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi. Authors: Burchill MA, Nardelli DT, England DM, DeCoster DJ, Christopherson JA, Callister SM, Schell RF Infect. Immun., 2003;71(6):3437-42. Species: Mouse Sample Type: In Vivo Application: In vivo
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	E. coli-derived recombinant mouse IL‑17 Thr22-Ala158 Accession # Q62386
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Mouse
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Interleukin 17 (also known as CTLA-8) is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. cDNA clones encoding IL-17 have been isolated from activated rat, mouse and human T cells. Mouse IL-17 cDNA encodes a 158 amino acid (aa) residue precursor protein with a 21 amino acid residue signal peptide that is cleaved to yield the 137 aa residue mature IL-17. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. At the amino acid level, mIL-17 shows 57% and 87% sequence identity with herpesvirus and rat IL-17, respectively. An IL-17 specific mouse cell surface receptor (IL-17 R) has been cloned. While the expression of IL-17 mRNA is restricted to activated alpha beta TCR+CD4-CD8-T cells, the expression of mIL-17 R mRNA has been detected in virtually all cells and tissues tested. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-kappa B and costimulation of T cell proliferation.
运输条件	Blue Ice
存放说明	-20℃
参考文献	Kennedy, J. et al. (1996) J. Interferon Cytokine Res. 16:611. Yao, Z. et al. (1995) J. Immunol. 155:5483. Yao, Z. et al. (1995) Immunity 3:811. Rouvier, E. et al. (1993) J. Immunol. 150:5445.

参考图片

IL‑6 Secretion Induced by
IL‑17 and Neutralization by Mouse IL‑17 Antibody. Recombinant Mouse IL‑17 (Catalog # 421-ML) stimulates IL‑6 secretion in the NIH‑3T3 mouse embryonic fibroblast cell line in a dose-dependent manner (orange line), as measured by the Mouse IL‑6 Quantikine ELISA Kit (Catalog # M6000B). IL‑6 secretion elicited by Recombinant Mouse IL‑17 (10 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL‑17 Monoclonal Antibody (Catalog # MAB421). The ND₅₀ is typically
0.05-0.15 µg/mL.