Human Common gamma Chain MAb (Clone 38024) (500 UG)【科瑞奥博】

产品中心

当前位置：首页>产品中心

Human Common gamma Chain MAb (Clone 38024) (500 UG)

货号： MAB284-500 基本售价： 10360.6 元规格： 500 ug

产品信息

概述
货号	MAB284-500
别名	CD132 antigen; CD132; CIDX; combined immunodeficiency, X-linked; common cytokine receptor gamma chain; common gamma-chain; cytokine receptor common subunit gamma; gamma(c); IL-2 R gamma; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL2RG; IL-2RG; IMD4; interleukin 2 receptor, gamma; Interleukin-2 receptor subunit gamma; P64; SCIDX; SCIDX1; severe combined immunodeficiency
全称	IL-2 Receptor gamma
反应种属	Human
应用	Neutralization
目标/特异性	Detects human Common gamma Chain/IL‑2 R gamma in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL‑2 R alpha, rhIL‑2 R beta, rhIL‑1 RI, rhIL‑1 RII, rhIL‑4 R, rhIL‑6 R, rhIL‑7 R, or rhIL‑10 R is observed.
使用方法	Neutralization: Measured by its ability to neutralize IL‑2-induced proliferation in the MO7e human megakaryocytic leukemic cell line. Avanzi, G. et al. (1988) Br. J. Haematol. 69:359. The Neutralization Dose (ND₅₀) is typically 2.5-15 µg/mL in the presence of 30 ng/mL Recombinant Human IL‑2.
来源	Monoclonal Mouse IgG₁ Clone # 38024
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3561 (Human); 16186 (Mouse)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. Authors: Rose T, Lambotte O, Pallier C, Delfraissy JF, Colle JH J. Immunol., 2009;182(12):7389-97. Species: Human Sample Type: Plasma Application: ELISA Development Selective induction of eotaxin release by interleukin-13 or interleukin-4 in human airway smooth muscle cells is synergistic with interleukin-1beta and is mediated by the interleukin-4 receptor alpha-chain. Authors: Hirst SJ, Hallsworth MP, Peng Q Am. J. Respir. Crit. Care Med., 2002;165(8):1161-71. Species: Human Sample Type: Cell Lysates Application: WB
纯化方式	Protein A or G purified from ascites
免疫原	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Common gamma Chain/IL‑2 R gamma Leu23-Asn254 Accession # P31785
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	The gamma chain of the high affinity functional human IL-2 receptor complex belongs to the hematopoietin receptor family. IL-2 R gamma is a 369 amino acid residue protein consisting of a 22 residue signal sequence, a 232 residue extracellular domain, a 29 residue transmembrane domain and an 86 residue cytoplasmic domain. Although IL-2 R gamma by itself does not bind IL-2 with any appreciable affinity, it is required for IL-2 receptor signaling. Besides IL-2, the gamma chain has been shown to be a component of the functional receptor complexes for IL-4, IL-7, IL-9 and IL-15. It has been proposed that IL-2 R gamma be designated the common gamma chain ( gamma _c). The site of molecular defects in X-linked SCID (severe combined immunodeficiency) has now been mapped to the IL-2 R gamma gene.
运输条件	Blue Ice
存放说明	-20℃
参考文献	Common gamma Chain Receptor Family Cytokines and Receptors in Allergy and Asthma Cytokines and Receptors in Tfh Cell Differentiation and Function Human CD Marker Products Interactive Pathway: IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types Interactive Pathway: IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types Interactive Pathway: IL-2 Signaling Pathways Interactive Pathway: IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types Interactive Pathway: IL-4 Signaling Pathways Isolation, Culture, and Identification of Natural Killer Cells Natural Killer T (NKT) Cells Preeclampsia Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) T Cell Cytokine Signaling Th2 Cells Th9 Cells

参考图片

Cell Proliferation Induced by IL‑2 and Neutralization by Human Common gamma Chain/
IL‑2 R gamma Antibody. Recombinant Human IL‑2 (Catalog # 202-IL) stimulates proliferation in the MO7e human megakaryocytic leukemic cell line in a dose-dependent manner (orange line), as measured by Resazurin (Catalog # AR002). Proliferation elicited by Recombinant Human IL‑2 (30 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human Common gamma Chain/IL‑2 R gamma Monoclonal Antibody (Catalog # MAB284). The ND₅₀ is typically 2.5-15 µg/mL.