Ms IFN Receptor 1 NALE MAR1-5A3 500ug
货号：
561183 基本售价：
7434.0 元 规格：
500ug
产品信息
概述| 货号 | 561183 |
| 描述 | The MAR1-5A3 monoclonal antibody specifically binds to the IFN-α/β Receptor 1 (also known as Interferon-alpha/beta Receptor 1; Type I Interferon Receptor 1 or IFNAR-1) subunit. A variety of cell types including lymphocytes, monocytes/macrophages, dendritic cells, and fibroblasts can be stimulated or induced by viral and microbial infections to produce and secrete type I interferons, including Interferon-alpha (IFN-α) subtypes and Interferon-beta (IFN- β). IFN-α subtypes and IFN-β bind to a common heterodimeric receptor complex (also known as the Type I IFN Receptor or IFN-α/β Receptor) that is comprised of transmembrane glycoprotein IFNAR-1 and IFNR-2 subunits and is expressed on most cell types. Upon ligand binding, IFNAR-1 and IFNAR-2 signal cellular responses. Type I interferons are multifunctional proteins that can induce antiviral states in cells as well as regulate the activation, growth, proliferation, differentiation and viability of various cell types including cells that mediate innate and adaptive immunity as well as autoimmune diseases. The MAR1-5A3 monoclonal antibody blocks Type I IFN receptor signaling and in vitro and in vivo biologic responses caused by type I interferons. The MAR1-5A3 antibody has also been reported to be useful for immunofluorescent staining and flow cytometric analysis, immunoprecipitation and Western blot analysis of IFNAR-1. |
| 别名 | Interferon-alpha/beta Receptor 1; IFN-R-1; Ifar; Ifnar; Ifrc; Infar |
| 同种亚型 | IgG1,κ |
| 反应种属 | Mouse (QC Testing) |
| 来源宿主 | Mouse |
| 使用方法 | FC |
性能| 供应商 | BD Pharmingen |
| 免疫原 | Mouse Ifnar1 extracellular domain DNA |
| 标记 | NA/LE |
| 存放说明 | Store undiluted at 4°C.The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.This preparation contains no preservatives, thus it should be handled under aseptic conditions.
|
| 存储溶液 | No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2µm sterile filtered. Endotoxin level is ≤0.01 EU/µg (≤0.001 ng/µg) of protein as determined by the LAL assay. |
| 浓度 | 1.0 mg/ml |
