Human CXCR4 (Fusin) MAb (Clone 44717) (100 UG)【科瑞奥博】

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Human CXCR4 (Fusin) MAb (Clone 44717) (100 UG)

货号： MAB173-100 基本售价： 3985.6 元规格： 100 ug

产品信息

概述
货号	MAB173-100
别名	CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; D2S201ESDF-1 receptor; FB22; Fusin; HM89NPYRL; HSY3RR; LAP3; LCR1; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3RWHIM; NPYR; NPYY3R; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor
反应种属	Human
应用	Flow Cytometry(2.5 µg/10⁶cells)
目标/特异性	Reacts specifically with human and non-human cells expressing human CXCR4 (fusin) as detected by flow cytometry. It will also react with cells expressing feline CXCR4 but not rat CXCR4. This antibody does not cross-react with other chemokine receptors.
使用方法	Flow Cytometry: 2.5 µg/10⁶cells Neutralization: Measured by its ability to neutralize CXCL12/SDF‑1 alpha -induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CXCR4. The Neutralization Dose (ND₅₀) is typically 1-5 µg/mL in the presence of 1 ng/mL Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha.
来源	Monoclonal Mouse IgG_2B Clone # 44717
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Novel role for NFAT3 in ERK-mediated regulation of CXCR4. Authors: Huang, Keven, Kiefer, Christin, Kamal, Adeela PLoS ONE, 2014;9(12):e115249. Species: Human Sample Type: Cell Lysates Application: WB Production of hepatocyte-like cells from human pluripotent stem cells. Authors: Hannan, Nicholas, Segeritz, Charis-P, Touboul, Thomas, Vallier, Ludovic Nat Protoc, 2013;8(2):430-7. Species: Human Sample Type: Whole Cells Application: ICC A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment. Authors: Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L, Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR Cancer Res., 2012;72(1):66-75. Species: Human Sample Type: Whole Tissue Application: IHC Paraffin-embedded CXCR7 functions as a scavenger for CXCL12 and CXCL11. Authors: Naumann U, Cameroni E, Pruenster M, Mahabaleshwar H, Raz E, Zerwes HG, Rot A, Thelen M PLoS ONE, 2010;5(2):e9175. Species: Human Sample Type: Whole Cells Application: ICC CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1. Authors: Kollmar O, Rupertus K, Scheuer C, Nickels RM, Haberl GC, Tilton B, Menger MD, Schilling MK Int. J. Cancer, 2010;126(6):1302-15. Species: Mouse Sample Type: In Vivo Application: In vivo Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. Authors: Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S J. Exp. Med., 2009;206(1):249-58. Species: Human Sample Type: Whole Cells Application: Blocking CCL28 is increased in human Helicobacter pylori-induced gastritis and mediates recruitment of gastric immunoglobulin A-secreting cells. Authors: Hansson M, Hermansson M, Svensson H, Elfvin A, Hansson LE, Johnsson E, Sjoling A, Quiding-Jarbrink M Infect. Immun., 2008;76(7):3304-11. Species: Human Sample Type: Whole Cells Application: Flow pVHL co-ordinately regulates CXCR4/CXCL12 and MMP2/MMP9 expression in human clear-cell renal cell carcinoma. Authors: Struckmann K, Mertz K, Steu S, Storz M, Staller P, Krek W, Schraml P, Moch H J. Pathol., 2008;214(4):464-71. Species: Human Sample Type: Whole Cells Application: ICC Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. Authors: Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH J. Immunol., 2007;179(6):3724-33. Species: Human Sample Type: Whole Cells Application: Flow The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities. Authors: Ponte AL, Marais E, Gallay N, Langonne A, Delorme B, Herault O, Charbord P, Domenech J Stem Cells, 2007;25(7):1737-45. Species: Human Sample Type: Whole Cells Application: Flow Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Authors: Curiel, Tyler J, Coukos, George, Zou, Linhua, Alvarez, Xavier, Cheng, Pui, Mottram, Peter, Evdemon-Hogan, Melina, Conejo-Garcia, Jose R, Zhang, Lin, Burow, Matthew, Zhu, Yun, Wei, Shuang, Kryczek, Ilona, Daniel, Ben, Gordon, Alan, Myers, Leann, Lackner, Andrew, Disis, Mary L, Knutson, Keith L, Chen, Lieping, Zou, Weiping Nat Med, 2004;10(9):942-9. Species: Human Sample Type: Whole Cells Application: Neut Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. Authors: Lim HW, Hillsamer P, Kim CH J. Clin. Invest., 2004;114(11):1640-9. Species: Human Sample Type: Whole Cells Application: ICC Factors that increase the effective concentration of CXCR4 dictate feline immunodeficiency virus tropism and kinetics of replication. Authors: de Parseval A, Ngo S, Sun P, Elder JH J. Virol., 2004;78(17):9132-43. Species: Feline Sample Type: Whole Cells Application: Flow Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry. Authors: Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D FEBS Lett., 2003;546(2):300-6. Species: Human Sample Type: Whole Cells Application: Flow Expression of CXCR4 on feline peripheral blood mononuclear cells: effect of feline immunodeficiency virus infection. Authors: Willett BJ, Cannon CA, Hosie MJ J. Virol., 2003;77(1):709-12. Species: Feline Sample Type: Whole Cells Application: Flow CXCR4 function requires membrane cholesterol: implications for HIV infection. Authors: Nguyen DH, Taub D J. Immunol., 2002;168(8):4121-6. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	3T3 cells transfected with human CXCR4
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	CXCR4 is a G-protein-linked seven transmembrane spanning receptor thatbinds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factorfor T-cell tropic HIV-1 and -2 viral entry into cells.
运输条件	Blue Ice
存放说明	-20℃
参考文献	Acute Myeloid Leukemia B Cell Chemotaxis, Migration, and Adhesion B Cell Markers Cancer Biomarkers Cancer Stem Cell Markers Chemokine Receptors Chemokines and Receptors in Allergy and Asthma Chemokines and Receptors in Angiogenesis Chemokines and Receptors in Tfh Cell Differentiation and Function CXCR4: A Receptor for Extracellular Ubiquitin Cytokine Upregulation of HIV Coreceptors Endothelial Cell Differentiation Markers Endothelial Progenitor and Endothelial Cell Markers Endothelial Progenitor Cell Markers gamma delta T Cells Hematopoietic Stem Cell Markers Hepatic Endoderm Hepatic Endoderm Cell Markers HIF Transcription Factors Human CD Marker Products Infectious Diseases Megakaryocytes Neural Stem Cell Markers Neuroinflammation Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) Somite Markers T Cell Migration/Adhesion Th2 Cells

参考图片

Chemotaxis Induced by CXCL12/SDF‑1 alpha and Neutralization by Human CXCR4 Antibody. Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha (Catalog # 350-NS) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR4 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha (1 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human CXCR4 Monoclonal Antibody (Catalog # MAB173). The ND₅₀ is typically 1-5 µg/mL.