Human CXCR4 (Fusin) MAb (Clone 44708) (100 UG)【科瑞奥博】

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Human CXCR4 (Fusin) MAb (Clone 44708) (100 UG)

货号： MAB171-100 基本售价： 3985.6 元规格： 100 ug

产品信息

概述
货号	MAB171-100
别名	CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; D2S201ESDF-1 receptor; FB22; Fusin; HM89NPYRL; HSY3RR; LAP3; LCR1; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3RWHIM; NPYR; NPYY3R; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor
反应种属	Human
应用	Neutralization
目标/特异性	Reacts specifically with human and non-human cells expressing human CXCR4 (fusin) as detected by flow cytometry. It will also react with cells expressing feline CXCR4 but not rat CXCR4. This antibody does not cross-react with other chemokine receptors.
使用方法	Neutralization: Measured by its ability to neutralize CXCL12/SDF‑1 alpha -induced chemotaxis in the BaF3 mouse pro‑B cell line transfected with human CXCR4. The Neutralization Dose (ND₅₀) is typically 0.2-1.2 µg/mL in the presence of 1 ng/mL Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha.
来源	Monoclonal Mouse IgG_2A Clone # 44708
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices Proc Natl Acad Sci USA, 2016;0(0):. Species: Human Sample Type: Whole Cells Application: IHC Fresh ZAP-70 promotes the infiltration of malignant B-lymphocytes into the bone marrow by enhancing signaling and migration after CXCR4 stimulation. Authors: Calpe E, Purroy N, Carpio C, Abrisqueta P, Carabia J, Palacio C, Castellvi J, Crespo M, Bosch F PLoS ONE, 2013;8(12):e81221. Species: Human Sample Type: Whole Cells Application: Neut CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis. Authors: Ouwehand K, Santegoets SJ, Bruynzeel DP, Scheper RJ, de Gruijl TD, Gibbs S Eur. J. Immunol., 2008;38(11):3050-9. Species: Human Sample Type: Whole Cells Application: Neut Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Authors: Ao M, Franco OE, Park D, Raman D, Williams K, Hayward SW Cancer Res., 2007;67(9):4244-53. Species: Human Sample Type: Cell Lysates Application: WB Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus. Authors: Wald O, Pappo O, Safadi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, Hanna J, Zamir G, Eid A, Mandelboim O, Spengler U, Galun E, Peled A Eur. J. Immunol., 2004;34(4):1164-74. Species: Human Sample Type: Whole Tissue Application: IHC Paraffin-embedded CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Authors: Singh S, Singh UP, Grizzle WE, Lillard JW Lab. Invest., 2004;84(12):1666-76. Species: Human Sample Type: Whole Cells Application: Neut Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry. Authors: Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D FEBS Lett., 2003;546(2):300-6. Species: Human Sample Type: Whole Cells Application: Flow CXCR4 function requires membrane cholesterol: implications for HIV infection. Authors: Nguyen DH, Taub D J. Immunol., 2002;168(8):4121-6. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from ascites
免疫原	3T3 cells transfected with human CXCR4
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	CXCR4 is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T cell tropic HIV‑1 and -2 viral entry into cells.
运输条件	Blue Ice
存放说明	-20℃
参考文献	Acute Myeloid Leukemia B Cell Chemotaxis, Migration, and Adhesion B Cell Markers Cancer Biomarkers Cancer Stem Cell Markers Chemokine Receptors Chemokines and Receptors in Allergy and Asthma Chemokines and Receptors in Angiogenesis Chemokines and Receptors in Tfh Cell Differentiation and Function CXCR4: A Receptor for Extracellular Ubiquitin Cytokine Upregulation of HIV Coreceptors Endothelial Cell Differentiation Markers Endothelial Progenitor and Endothelial Cell Markers Endothelial Progenitor Cell Markers gamma delta T Cells Hematopoietic Stem Cell Markers Hepatic Endoderm Hepatic Endoderm Cell Markers HIF Transcription Factors Human CD Marker Products Infectious Diseases Megakaryocytes Neural Stem Cell Markers Neuroinflammation Receptors in the Jak/STAT Pathway Regulatory T Cells (Tregs) Somite Markers T Cell Migration/Adhesion Th2 Cells

参考图片

Chemotaxis Induced by CXCL12/SDF‑1 alpha and Neutralization by Human CXCR4 Antibody. Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha (Catalog # 350-NS) chemoattracts the BaF3 mouse pro‑B cell line transfected with human CXCR4 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin (Catalog # AR002). Chemotaxis elicited by Recombinant Human/Feline/Rhesus Macaque CXCL12/SDF‑1 alpha (1 ng/mL) is neutralized (green line) by increasing concentrations of Human CXCR4 Monoclonal Antibody (Catalog # MAB171). The ND₅₀ is typically 0.2-1.2 µg/mL.