| 货号 | MAB15951 |
| 别名 | EC 3.4.21; EC 3.4.21.-; EC 3.4.21.4; Hippostasin; hK11; kallikrein 11; kallikrein-related peptidase 11; KLK11; MGC33060; PRSS20kallikrein-11; Serine protease 20; TLSPhippostasin; Trypsin-like protease |
| 反应种属 | Human |
| 应用 | Neutralization |
| 目标/特异性 | Detects human Kallikrein 11 in direct ELISAs. |
| 使用方法 | Neutralization: Measured by its ability to neutralize Recombinant Human Kallikrein 11 (1 µg/mL, Catalog # 1595-SE) cleavage of the fluorogenic peptide substrate VLK-SBzl (0.1 mM). The Neutralization Dose (ND50) is typically 2.4 µg/mL. |
| 来源 | Monoclonal Rat IgG2A Clone # 371604 |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 11012 (Human) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Mouse myeloma cell line NS0-derived recombinant human Kallikrein 11 Glu51-Asn282 Accession # Q9UBX7 |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 溶解方法 | Reconstitute at 0.5 mg/mL in sterile PBS. |
| 背景 | The human tissue kallikrein (KLK) gene family contains 15 members that play important roles in cancer. Notably, kallikrein-1, also known as tissue kallikrein, cleaves kininogen to release the vasoactive kinin peptide, bradykinin or lysyl-bradykinin. Kallikrein-3, called prostate specific antigen (PSA), is an established tumor marker that aids in the diagnosis, staging, and follow up of prostate cancer. Kallikrein-4 is specifically expressed in the prostate and over-expressed in prostate cancer. Kallikrein-5 is widely expressed but found at high levels in skin, breast, brain and testis; over-expression is an indicator of poor prognosis in ovarian cancer. Kallikrein-8 is expressed in the brain and is a novel marker of ovarian and cervical cancer. Human plasma kallikrein, a serine protease, is synthesized in the liver and circulates in the plasma bound to high molecular weight (HMW) kininogen or as a free zymogen. Once activated by its physiological activator, coagulation factor XII, it displays endopeptidase activity towards peptide bonds after arginine (preferred) and lysine. It cleaves HMW kininogen, its major physiological substrate, to release the potent vasodilator peptide bradykinin. It is also able to cleave a number of inactive precursor proteins to generate active products, such as plasminogen and prourokinase. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
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