Human IFN-alpha MAb (Clone MMHA-8) (50 UG)
货号：
21110-1 基本售价：
3103.2 元 规格：
50 ug
产品信息
概述| 货号 | 21110-1 |
| 别名 | IFNalpha; IFN-alpha |
全称 | Interferon alpha | | 反应种属 | Human |
| 应用 | ELISA,Neutralization |
| 目标/特异性 | Neutralizes human interferon alpha; binds to human interferon alpha with high affinity (KA ≈ 109M-1) |
| 使用方法 | ELISA: Optimal dilutions should be determined by each laboratory for eachapplication.
Neutralization: One neutralization unit is the amount of antiserum required to neutralize one unit of human interferon alpha (Hu-IFN-alpha ) to a 50% endpoint. Interferon was titrated with the use of the cytopathic effect inhibition assay as described [Rubinstein, S., Familletti, P.C., and Pestka, S. (1981) "Convenient Assay for Interferons," J. Virol. 37, 755-758; Familletti, P.C., Rubinstein, S., and Pestka, S. (1981) "A Convenient and Rapid Cytopathic Effect Inhibition Assay for Interferon," in Methods in Enzymology, Vol. 78 (S. Pestka, ed.), Academic Press, New York, 387-394]. In this antiviral assay for interferon, about 1 unit/ml of interferon is the quantity necessary to produce a cytopathic effect of 50%. The units are determined with respect to the international reference standard for Hu-IFN-alpha provided by the National Institutes of Health [see Pestka, S. (1986) "Interferon Standards and General Abbreviations," in Methods in Enzymology (S. Pestka, ed.), Academic Press, New York 119, 14-23].
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| 来源 | Monoclonal Mouse IgG2B Clone # MMHA-8 |
| 产品组分 | |
性能| 供应商 | R&D Systems |
| Entrez Gene IDs | 3440 (Human) |
| 纯化方式 | Protein A or G purified from hybridoma culture supernatant |
| 免疫原 | Human Leukocyte Interferon |
| 内毒素水平 | <1.0 EU per 1 μg of the antibody by the LAL method. |
| 生物活性 | Human |
| 标记 | Unconjugated |
| 背景 | Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells. |
| 运输条件 | Dry Ice |
| 存放说明 | -80℃ |
| 参考文献 | - B Cell Chemotaxis, Migration, and Adhesion
- Cytokines and Receptors in Angiogenesis
- IL-10/Interferon Family
- Infectious Diseases
- Plasmacytoid Dendritic Cells
- Th9 Cells
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