Human Integrin alpha V beta 5 MAb (Clone P5H9) (25 UG)【科瑞奥博】

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Human Integrin alpha V beta 5 MAb (Clone P5H9) (25 UG)

货号： MAB2528-SP 基本售价： 1467.3 元规格： 25 ug

产品信息

概述
货号	MAB2528-SP
别名	Integrin alpha V beta 5
反应种属	Human
应用	Flow Cytometry(2.5 µg/10⁶cells) Immunocytochemistry(8-25 µg/mL)
目标/特异性	Detects human Integrin alpha V beta 5. Recognizes the human Integrin alpha V beta 5 heterodimer and does not recognize the alpha V subunit in association with any other beta subunits.
使用方法	Flow Cytometry: 2.5 µg/10⁶cells Immunoprecipitation: Wayner, E.A. et al. (1991) J. Cell Biol. 113:919. Adhesion Blockade: Wayner, E.A. et al. (1991) J. Cell Biol. 113:919. Immunocytochemistry: 8-25 µg/mL
来源	Reconstitute at 0.5 mg/mL in sterile PBS.
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	3685 (Human)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Arg-Gly-Asp (RGD)-Modified E1A/E1B Double Mutant Adenovirus Enhances Antitumor Activity in Prostate Cancer Cells In Vitro and in Mice. Authors: Shen Y, Yang F, Wang H, Cai Z, Xu Y, Zhao A, Su Y, Zhang G, Zhu S PLoS ONE, 2016;11(1):e0147173. Species: Human Sample Type: Whole Cells Application: Flow Degradation of internalized alphaVbeta5 integrin is controlled by uPAR bound uPA: effect on beta1 integrin activity and alpha-SMA stress fiber assembly. Authors: Wang L, Pedroja BS, Meyers EE, Garcia AL, Twining SS, Bernstein AM PLoS ONE, 2012;7(3):e33915. Species: Human Sample Type: Whole Cells Application: Neut Analysis of HLDA9 mAbs on plasmacytoid dendritic cells. Authors: Cabezon R, Sintes J, Llinas L, Benitez-Ribas D Immunol. Lett., 2011;134(2):167-73. Species: Human Sample Type: Whole Cells Application: Flow
纯化方式	Protein A or G purified from hybridoma culture supernatant
免疫原	HT1080 human fibrosarcoma cell line
内毒素水平	<0.10 EU per 1 μg of the antibody by the LAL method.
生物活性	Human
标记	Unconjugated
溶解方法	Reconstitute at 0.5 mg/mL in sterile PBS.
背景	Integrins are heterodimeric receptors comprised of an alpha and a beta subunit. Integrin alpha V (CD51) associates with several different beta subunits, but Integrin beta 5 associates exclusively with the alpha V subunit. Integrin alpha V beta 5, also known as Integrin alpha V beta S and Integrin alpha V beta 3B, is a transmembrane heterodimeric protein that functions as a receptor for Vitronectin. It is expressed on hepatoma cells, fibroblasts and carcinoma cells.
运输条件	Blue Ice
存放说明	4℃
参考文献	Actin Stress Fibers and Focal Adhesions During EMT Adhesion Molecules Endothelial Cell Markers and Adhesion Molecules in Angiogenesis Epithelial Cell Polarity HGF/SF Activation of Integrins ICC / IHC Images: Integrin alpha V beta 5 Integrin Ligands at a Glance (J. Cell. Sci.) Integrin Subunit Interactions Integrins and Associated Molecules

参考图片

Integrin alpha V beta 5 in HT1080 Human Cell Line. Integrin alpha V beta 5 was detected in immersion fixed HT1080 human fibrosarcoma cell line using Human Integrin alpha V beta 5 Monoclonal Antibody (Catalog # MAB2528) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.